| 抑郁症相关执行功能障碍的磁共振成像研究进展 |
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| 引用本文： | 冯苏洋,邢炯,舒敏,刘加成. 抑郁症相关执行功能障碍的磁共振成像研究进展[J]. 国际放射医学核医学杂志, 2021, 45(12): 795-799. DOI: 10.3760/cma.j.cn121381-202012010-00117 |
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| 作者姓名： | 冯苏洋 邢炯 舒敏 刘加成 |
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| 作者单位： | 1.东南大学医学院影像医学与核医学专业，南京 210009;2.江苏省无锡市第三人民医院放射科 214043;3.东南大学附属中大医院核医学科，南京 210009 |
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| 摘 要： | 抑郁症患者常合并执行功能障碍，这种认知障碍会影响其日常生活质量及预后。执行功能需要额叶皮质、边缘系统、颞顶叶、丘脑、小脑、岛叶、脑干网状系统等协同作用，相应神经回路（主要包括默认模式网络、执行控制网络、突显网络和边缘系统）及其关键区域之间连接的破坏会导致执行功能的破坏。MRI可以非侵入性地显示大脑及其神经网络的结构和功能改变，识别抑郁症相关执行功能障碍及其治疗反应的异常表现，从而评估其功能背后相关的神经机制。笔者综述了目前抑郁症相关执行功能障碍的磁共振结构成像（包括弥散张量成像、形态结构成像）及功能成像的研究进展。
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| 关 键 词： | 抑郁症 执行功能 认知功能障碍 磁共振成像 |
| 收稿时间： | 2020-12-09 |
Advances in magnetic resonance imaging of depression-related executive dysfunction |
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| Suyang Feng,Jiong Xing,Min Shu,Jiacheng Liu. Advances in magnetic resonance imaging of depression-related executive dysfunction[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2021, 45(12): 795-799. DOI: 10.3760/cma.j.cn121381-202012010-00117 |
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| Authors: | Suyang Feng Jiong Xing Min Shu Jiacheng Liu |
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| Affiliation: | 1. Department of Imaging Medicine and Nuclear Medicine, Southeast University School of Medicine, Nanjing 210009, China;2. Department of Radiology, Wuxi Third People's Hospital in Jiangsu Province, Wuxi 214043, China;3. Department of Nuclear Medicine, Zhongda Hospital Southeast University, Nanjing 210009, China |
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| Abstract: | Depression is often associated with executive dysfunction, a cognitive impairment that can have an effect on quality of daily life and prognosis. Executive function requires the synergy among the frontal cortex, limbic system, temporal parietal lobe, thalamus, cerebellum, insular lobe, and brainstem reticular system. The damage of the corresponding neural circuit (mainly including the default mode network, executive control network, salience network, and limbic system) and the inter-regional connections of the important network components of these neural circuits leads to the destruction of executive function. MRI can noninvasively reveal structural and functional changes in the brain and its neural networks and can be used as a biomarker to identify depression-related executive dysfunction and its response to treatment to assess the related neural mechanisms underlying its function. In this work, the authors review the current research progress of structural (diffusion tensor imaging and morphological structural imaging) and functional MRI for depression-related executive dysfunction. |
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| Keywords: | Depressive disorder Executive function Cognitive dysfunction Magnetic resonance imaging |
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