| 某中学肺结核疫情中病例接触人群PPD试验结果 |
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| 引用本文： | 董小伟,林培歆,何俊磊,李建伟,余美玲,温文沛. 某中学肺结核疫情中病例接触人群PPD试验结果[J]. 中国学校卫生, 2021, 42(12): 1785-1788,1792. DOI: 10.16835/j.cnki.1000-9817.2021.12.007 |
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| 作者姓名： | 董小伟 林培歆 何俊磊 李建伟 余美玲 温文沛 |
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| 作者单位： | 广东省结核病控制中心流行病学监测室,广州 610630 |
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| 基金项目： | “十三五”国家科技重大专项2017ZX10201302 |
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| 摘 要： | 目的 探索结核菌素试验(PPD试验)在学校结核病疫情处置中对于界定密切接触者筛查范围的作用,为学校肺结核防治工作提供参考依据.方法 回顾性分析比较2019年8月广东省某中学发生肺结核疫情的高二年级与同期该校高一入学新生体检PPD试验结果,共1553名学生,并评估高二年级学生PPD试验流行病学分布与肺结核病例分布之间的潜...
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| 关 键 词： | 结核,肺 结核菌素试验 疾病暴发流行 学生 接触者追踪 |
| 收稿时间： | 2021-03-17 |
Tuberculin skin test in close contacts in case of school tuberculosis outbreak |
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| Affiliation: | Epidemiological Survenlance Unit, Centre for Tuberculosis Control of Guangdong Province, Guangzhou(610630), China |
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| Abstract: | Objective To evaluate the role of tuberculin skin test prified-protein derivative (PPD) in defining the screening scope of close contacts of tuberculosis cases in disposal of tuberculosis outbreak in schools. Methods In a senior middle school in August 2019, 1 553 students of the grade two were tested by PPD because of a school tuberculosis outbreak. PPD results were compared to grade one students without any association with this tuberculosis epidemic, who were also tested by PPD when beginning school. Potential association between PPD distribution characteristics and tuberculosis case distribution were analyzed. Results Twenty-nine grade two students were diagnozed as tuberculosis infection, seven of which were PPD-positive, and with the same MIRU-VNTR genotype. In grade one, 0.1% (1/796) student showed strong PPD-positive, 34.3% (273/796) student showed positive. For grade two students, significant higher rate of strong PPD-positive [5.9% (45/757)], and PPD-positive [52.0% (394/757)] were observed (χ2=45.71, 49.90, P < 0.01). Proportion of strong PPD-positive in the first floor of the teaching building (19.4%), where tuberculosis cases clustered, was significantly higher than that in other floors (χ2=89.81, P < 0.01); Number of strong PPD-positive students increased with TB cases in each floor of the teaching building (r=0.99, P < 0.01). Proportion of strong PPD-positive and PPD-positive in floors of the dormitory, where TB cases lived, was significantly higher than in other floors (χ2=49.4, 64.9, P < 0.01). Number of strong PPD-positive and PPD-positive students increased with TB cases in each floor of the teaching building (r=0.84, 0.56, P < 0.01). Conclusion Strong PPD-positive rate well reflects tuberculosis infection of close contacts, and is recommended for defining the scope of screening. |
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