| 上海市闵行区青春期女生甲状腺激素水平及影响因素分析 |
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| 引用本文： | 何丹丹,温晓飒,付晔,徐晓莉,陶士吉,苏华林,徐东丽,王娜. 上海市闵行区青春期女生甲状腺激素水平及影响因素分析[J]. 中国学校卫生, 2021, 42(3): 430-435. DOI: 10.16835/j.cnki.1000-9817.2021.03.027 |
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| 作者姓名： | 何丹丹 温晓飒 付晔 徐晓莉 陶士吉 苏华林 徐东丽 王娜 |
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| 作者单位： | 1.上海市闵行区疾病预防控制中心公共卫生管理科，201101 |
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| 基金项目： | 闵行区自然科学研究项目2018MHZ010复旦-闵行康联体合作项目2019FM07 |
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| 摘 要： | 目的 观察上海市闵行区青春期女生的甲状腺激素水平,并探讨其可能的影响因素.方法 2019年1-3月采用分阶段整群抽样方法,分别在上海市闵行区东、南、北和中片各选取1所初中,将其新入学的预初女生共386名纳入研究.对研究对象进行体格检查,并收集其尿样及血样以检测尿碘及甲状腺激素水平;采用青春发育量表(Pubertal D...
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| 关 键 词： | 青春期 甲状腺激素类 生长和发育 回归分析 学生 女(雌)性 |
| 收稿时间： | 2020-07-29 |
Analysis of thyroid hormone level and its influencing factors among pubertal girls in Minhang District of Shanghai |
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| Affiliation: | 1.Department of Public Health Managemet, Shanghai Minhang District Center for Disease Control and Prevention, Shanghai(201101), China |
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| Abstract: | Objective To investigate thyroid hormone concentration and associated factors among pubertal girls in Minhang District of Shanghai. Methods From January to March 2019, a stratified sampling method was used to select junior high schools from the east, south, north, and middle areas in Minhang district. A total of 386 girls of grade 6 in selected schools were included in the study. Physical examination was conducted, and their urine and blood samples were collected to determine urinary iodine concentration (UIC) and thyroid function. Puberty Development Self-rating Scale (PDS) was used to define the pubertal stage. Logistic regression models were conducted to analyze the associations between pubertal stage and thyroid function. Results The median urinary iodine concentration was 163.57(106.57, 232.96) μg/L. The geometric mean values of TSH, TT3, FT3 and FT4 were 0.29 mU/L, 0.26 nmol/L, 0.68 pmol/L and 1.18 pmol/L.The mean value of TT4 was 91.64 nmol / L. The abnormal rates of TGAb and TPOAb were 6.22% and 4.15%. The rate of abnormal TGAb combined with abnormal TPOAb was 3.68%. Girls in puberty and post-puberty had the lower level of TT4 (OR=0.47, 0.43) as compared with girls in pre-puberty stage. Obese girls had higher level of TT3(OR=9.08, 95%CI=1.52-54.07). With the increase of exercise time(0.5-1, >1 h/d), FT4 level was increased (OR=2.45, 2.19). TSH levels were significantly higher in girls with higher TGAb and TPOAb. Girls had higher TT4 or FT4 levels if their TGAb levels were higher and TPOAb levels were normal. Conclusion There is an association between pubertal stage, obesity, exercise and thyroid function in school-aged girls during puberty in iodine sufficient areas. TSH, FT4 and TT4 levels are correlated with TGAb and TPOAb levels. |
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