| Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl-cyclopropane Carbox Amide in Different Solvents |
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| 引用本文： | 石晓华,周彩荣,高玉国,陈新志. Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl-cyclopropane Carbox Amide in Different Solvents[J]. 中国化学工程学报, 2006, 0(4) |
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| 作者姓名： | 石晓华 周彩荣 高玉国 陈新志 |
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| 作者单位： | College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China College of Chemical Engineering Zhengzhou University Zhengzhou 450002 China，College of Chemical Engineering Zhengzhou University Zhengzhou 450002 China，College of Chemical Engineering Zhengzhou University Zhengzhou 450002 China，College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China |
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| 摘 要： | 1 INTRODUCTION (S)-(+)-2,2-dimethylcyclopropane carbox amide [(+)-DMCPCA, Fig.1] is a key intermediate of Cilas- tatin, an inhibitor of dehydropeptidase-I. As the syner- gist of imipenem (an antibiotic drug), cilastatin is widely used in clinical applications and has prosper- ous prospects[1]. In industrial manufacture[2―6], as the optical intermediate, the chemical and optical purity of (+)-DMCPCA would affect the quality of cilastatin. So, the separation and purification are impo…
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Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl-cyclopropane Carbox Amide in Different Solvents |
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| SHI Xiaohua a,b,ZHOU Cairong b,GAO Yuguo b and CHEN Xin-zhi a, a College of Materials Science and Chemical Engineering,Zhejiang University,Hangzhou ,China b College of Chemical Engineering,Zhengzhou University,Zhengzhou ,China. Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl-cyclopropane Carbox Amide in Different Solvents[J]. Chinese Journal of Chemical Engineering, 2006, 0(4) |
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| Authors: | SHI Xiaohua a b ZHOU Cairong b GAO Yuguo b CHEN Xin-zhi a a College of Materials Science Chemical Engineering Zhejiang University Hangzhou China b College of Chemical Engineering Zhengzhou University Zhengzhou China |
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| Affiliation: | SHI Xiaohua a,b,ZHOU Cairong b,GAO Yuguo b and CHEN Xin-zhi a,* a College of Materials Science and Chemical Engineering,Zhejiang University,Hangzhou 310027,China b College of Chemical Engineering,Zhengzhou University,Zhengzhou 450002,China |
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| Abstract: | (S)-(+)-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of de- hydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of (S)-(+)-2,2-dimethylcyclopropane carbox amide in toluene, di- chloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured us- ing the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation. The calculated values were good in agreement with the experimental values. |
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| Keywords: | solid-liquid equilibrium solubility (S)-(+)-2 2-dimethylcyclopropane carbox amide |
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