Synthesis of Small‐Sized,Porous, and Low‐Toxic Magnetite Nanoparticles by Thin POSS Silica Coating |
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| Authors: | Dr Swee Kuan Yen D Prathyusha Varma Wei Mei Guo Dr Vincent H B Ho Dr Vimalan Vijayaragavan Dr Parasuraman Padmanabhan Prof Kishore Bhakoo Prof Subramanian Tamil Selvan |
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| Affiliation: | 1. Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602 (Singapore);2. Molecular Engineering Laboratory, A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, #03‐13 Proteos, Singapore 138673 (Singapore);3. Singapore Bioimaging Consortium (SBIC), A*STAR (Agency for Science, Technology and Research), 11 Biopolis Way, #02‐02 Helios, Singapore 138667 (Singapore);4. Present address: The Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore 637553;5. National University of Singapore, Division of Biomedical Engineering, Faculty of Engineering, 7 Engineering Drive 1, Singapore 117576 (Singapore) |
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| Abstract: | In this communication, we report the synthesis of small‐sized (<10 nm), water‐soluble, magnetic nanoparticles (MNPs) coated with polyhedral oligomeric silsesquioxanes (POSS), which contain either polyethylene glycol (PEG) or octa(tetramethylammonium) (OctaTMA) as functional groups. The POSS‐coated MNPs exhibit superparamagnetic behavior with saturation magnetic moments (51–53 emu g?1) comparable to silica‐coated MNPs. They also provide good colloidal stability at different pH and salt concentrations, and low cytotoxicity to MCF‐7 human breast epithelial cells. The relaxivity data and magnetic resonance (MR) phantom images demonstrate the potential application of these MNPs in bioimaging. |
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| Keywords: | iron oxide ligand exchange magnetic resonance imaging magnetic properties nanoparticles |
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