| 人类端粒酶RNA和C-myc基因在子宫颈癌及癌前病变组织中的表达及其临床意义 |
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| 引用本文： | 熊汉真,杨嶽鑫,熊中堂,刘少颜,江庆萍. 人类端粒酶RNA和C-myc基因在子宫颈癌及癌前病变组织中的表达及其临床意义[J]. 肿瘤研究与临床, 2012, 24(8): 508-511 |
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| 作者姓名： | 熊汉真 杨嶽鑫 熊中堂 刘少颜 江庆萍 |
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| 作者单位： | 510515,广州医学院第三附属医院病理科 |
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| 摘 要： | 目的探讨人类端粒酶RNA（hTERC）及原癌基因C—myc在子宫颈病变中的表达。方法荧光原位杂交（FISH）法检测35例子宫颈上皮内瘤样病变（CIN）、8例浸润性子宫颈癌、19例炎性反应（对照）患者子宫颈组织中hTERC和C-myc基因的表达情况。结果3号染色体上的hTERC基因在慢性子宫颈炎组织、CINⅠ、CINⅡ～Ⅲ及子宫颈癌中的阳性率分别为5．3％（1／19）、16．7％（2／12）、87．0％（20／23）及87．5％（7／8），CINⅡ～Ⅲ及子宫颈癌中阳性率明显升高（χ^2=36．299，P〈0．01；χ^2=40．237，P〈0．01），原癌基因C-myc阳性率分别为5．3％（1／19）、8．3％（1／12）、78．3％（18／23）及62．5％（5／8），CINⅡ-Ⅲ及子宫颈癌中阳性率明显升高（χ^2=30．200，P〈0．01；χ^2=34．224，P〈0．01）。CINⅡ～Ⅲ及子宫颈癌中hTERC和C—myc基因表达之间呈正相关（r=0．514，P〈0．01）。结论3号染色体上hTERC基因及原癌基因C-myc的阳性表达与子宫颈癌的发生、发展可能有密切关系。
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| 关 键 词： | 子宫颈肿瘤 人类端粒酶RNA 基因 myc |
Clinical significance of human telomerase RNA component and C-myc gene expression in cervical cancer and precancerous lesions |
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| XIONG Han-zhen , YANG Yue-xin , XIONG Zhong-tang , LIU Shao-yan , JIANG Qing-ping. Clinical significance of human telomerase RNA component and C-myc gene expression in cervical cancer and precancerous lesions[J]. Cancer Research and Clinic, 2012, 24(8): 508-511 |
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| Authors: | XIONG Han-zhen YANG Yue-xin XIONG Zhong-tang LIU Shao-yan JIANG Qing-ping |
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| Affiliation: | . Department of Pathology, Third Hospital Affiliated to Guangzhou Medical College, Guangzhou 510515, China |
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| Abstract: | Objective To investigate the expression level of human telomerase RNA component （hTERC） and C-myc in cervical lesions. Methods Fluorescence in situ hybridization （FISH） was applied to detect hTERC and C-myc expression in 62 cases of cervical tissue including 35 cases of cervical intraepithelial neoplasia, 8 cases of invasive cervical cancer, 19 cases of inflammation as controls. Results The positive rates of hTERC on chromosome 3 in chronic cervicitis organizations, CIN Ⅰ , CIN Ⅱ - Ⅲ and cervical cancer were 5.3 % （1/19）, 16.7 %（2/12）, 87.0 % （20/23）, 87.5 % （7/8） （χ^2 = 36.299, χ^2 = 40.237, P 〈0.01）. The positive rates of C-mye in chronic cervical inflammation organization, CIN Ⅰ , CINⅡ - Ⅲ and cervical cancer were 5.3 % （1/19）, 8.3 % （1/12）, 78.3 % （18/23）, 62.5 % （5/8） （χ2 = 30.200, χ2 = 34.224, P 〈0.01 ）. The differences among groups were statistically significant, hTERC had a positively correlation with C-mye expression （r = 0.514, P 〈 0.01）. Conclusion The expression of hTERC and C-mye on chromosome 3 is closely related to cervical cancer progression. |
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| Keywords: | Uterine cervical neoplasms Human telomerase RNA component Genes myc |
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