| 中国男男性行为者HIV暴露前预防服药依从性影响因素的Meta分析 |
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| 引用本文： | 陈玉崟1,杨连招2,谭如意1,田怡1,姚胜男1,彭婉琳2,龙秀红1. 中国男男性行为者HIV暴露前预防服药依从性影响因素的Meta分析[J]. 现代预防医学, 2023, 0(11): 2088-2093. DOI: 10.20043/j.cnki.MPM.202210431 |
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| 作者姓名： | 陈玉崟1 杨连招2 谭如意1 田怡1 姚胜男1 彭婉琳2 龙秀红1 |
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| 作者单位： | 1. 广西中医药大学附属瑞康医院护理部，广西 南宁 530011；2. 广西中医药大学护理学院 |
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| 摘 要： | 目的 系统评价中国男男性行为者（MSM）人群PrEP服药依从性影响因素。方法 检索中文数据库（CNKI、WanFang、VIP、CBM）和英文数据库（PubMed、Cochrane Library、EMBASE、Web of Science），筛选关于中国MSM人群PrEP服药依从性影响因素的前瞻性队列研究，检索的时间从建库至2023年2月。经过文献筛选、资料提取和质量评价之后，采用RevMan 5.4将数据进行meta分析。结果 共纳入14篇文献，8 785例样本量进行meta分析，结果显示，受方（OR=3.37,95%CI:1.87～6.10）、药物效果的正向预期（OR=1.19,95%CI:1.01～1.41）、艾滋病知识水平（OR=1.82,95%CI:1.29～2.57）是我国MSM人群PrEP服药依从性的保护因素；担心药物不良反应（OR=0.89,95%CI:0.78～1.01）、服药后产生不良反应（OR=0.39,95%CI:0.22～0.68）、毒品的使用（OR=0.66,95%CI:0.50～0.86）是我国MSM人群PrEP服药依从性的危险因素。结论 现有研究证据表...
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| 关 键 词： | 暴露前预防 依从性 男男性行为者 艾滋病 中国 |
Meta-analysis of the factors affecting compliance with prophylaxis medication before HIV exposure in Chinese men who have sex with men |
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| CHEN Yu-yin,YANG Lian-zhao,TAN Ru-yi,TIAN Yi,YAO Sheng-nan,PENG Wan-lin,LONG Xiu-hong. Meta-analysis of the factors affecting compliance with prophylaxis medication before HIV exposure in Chinese men who have sex with men[J]. Modern Preventive Medicine, 2023, 0(11): 2088-2093. DOI: 10.20043/j.cnki.MPM.202210431 |
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| Authors: | CHEN Yu-yin YANG Lian-zhao TAN Ru-yi TIAN Yi YAO Sheng-nan PENG Wan-lin LONG Xiu-hong |
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| Affiliation: | *Nursing Department of Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530011, China |
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| Abstract: | Objective To systematically evaluate the influencing factors of PrEP drug compliance in Chinese men who have sex with men (MSM). Methods Chinese databases (CNKI, Wan Fang, VIP, and CBM) and English databases (PubMed, Cochrane Library, EMBASE, and Web of Science) were searched to screen the prospective cohort study on the influencing factors of PrEP drug compliance in Chinese MSM population. After literature screening, data extraction and quality evaluation, RevMan5.4 was used to analyze the data. Results A total of 14 articles were included, involving a total of 8 785 samples. The results showed that the protective factors of PrEP compliance of MSM population in China were the recipient(OR=3.37, 95%CI: 1.87-6.10), positive expectation of drug effect (OR=1.19, 95%CI: 1.01-1.41), and AIDS knowledge level (OR=1.82, 95%CI: 1.29-2.57). Concerns about adverse drug reactions (OR=0.89, 95%CI: 0.78-1.01), adverse drug reactions after taking drugs (OR=0.39, 95%CI: 0.22-0.68), and drug use (OR=0.66, 95%CI: 0.50-0.86) were the risk factors of PrEP compliance in Chinese MSM population. Conclusion Current evidence shows that the recipient, the positive expectation of drug effect and the level of AIDS knowledge are the protective factors of PrEP drug compliance in MSM population, and concerns about adverse drug reactions, adverse drug reactions, and drug use are the risk factors of PrEP drug compliance in MSM population. Early intervention should be carried out according to the controllable influencing factors to improve PrEP drug compliance. |
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| Keywords: | Pre-exposure prevention Compliance Men who have sex with men AIDS Analysis of influencing factors Meta analysis China |
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