| 晚期肺鳞癌靶向及免疫治疗进展 |
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| 引用本文： | 郭 帅,马 锐. 晚期肺鳞癌靶向及免疫治疗进展[J]. 现代肿瘤医学, 2019, 0(18): 3333-3337. DOI: 10.3969/j.issn.1672-4992.2019.18.041 |
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| 作者姓名： | 郭 帅 马 锐 |
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| 作者单位： | 中国医科大学肿瘤医院 辽宁省肿瘤医院，辽宁 沈阳 110042 |
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| 基金项目： | 吴阶平医学基金会临床科研专项资助基金项目（编号:320.6750.13148） |
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| 摘 要： | 肺癌是目前世界上发病率和死亡率最高的恶性肿瘤。其中，肺鳞癌（squamous-cell lung cancer,SQCLC）为一种常见的病理类型。近年来，许多学者针对肺鳞癌的靶向药物与免疫制剂进行大量的科学研究及临床试验，EGFR单克隆抗体、VEGFR的单克隆抗体、免疫检查点抑制剂等多种药物已在临床试验中取得了一定成果。本文对晚期肺鳞癌的分子靶向治疗及免疫治疗进行系统性的阐述，通过分析其在提高患者生存率、改善生存质量等方面取得的实质性研究成果，探讨目前临床上晚期肺鳞癌的靶向及免疫治疗进展及未来发展方向。
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| 关 键 词： | 肺鳞癌 晚期 靶向治疗 免疫治疗 |
Progress in targeting and immunotherapy for advanced squamous cell lung carcinoma |
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| Guo Shuai,Ma Rui. Progress in targeting and immunotherapy for advanced squamous cell lung carcinoma[J]. Journal of Modern Oncology, 2019, 0(18): 3333-3337. DOI: 10.3969/j.issn.1672-4992.2019.18.041 |
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| Authors: | Guo Shuai Ma Rui |
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| Affiliation: | Cancer Hospital of China Medical University,Liaoning Cancer Hospital & Institute,Liaoning Shenyang 110042,China. |
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| Abstract: | Lung cancer is currently the most malignant tumor with the highest morbidity and mortality in the world.Among them,squamous cell lung carcinoma is a common pathological type.In recent years,many scholars have carried out a large number of scientific research on squamous cell lung carcinoma,mainly for a large number of clinical trials of targeted drugs and immunological preparations for squamous cell lung carcinoma,EGFR monoclonal antibodies,VEGFR monoclonal antibodies,immunological checkpoint inhibitors,etc.A variety of drugs have achieved some results in clinical trials.This article aims to systematically elucidate the molecular targeted therapy and immunotherapy of advanced squamous cell lung carcinoma.By analyzing its research on improving patient survival rate and improving quality of life,this paper discusses the current targeting of advanced squamous cell lung carcinoma and progress in immunotherapy. |
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| Keywords: | squamous cell lung carcinoma late stage targeted therapy immunotherapy |
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