| 益生菌对Hp根除及其后续胃黏膜病理变化的影响研究 |
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| 引用本文： | 杨元生,彭卫斌,容海鹰,陈垦,朱雅丽,谢文瑞,叶东雯,张伟彬. 益生菌对Hp根除及其后续胃黏膜病理变化的影响研究[J]. 中华全科医学, 2019, 17(5): 749-751. DOI: 10.16766/j.cnki.issn.1674-4152.000782 |
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| 作者姓名： | 杨元生 彭卫斌 容海鹰 陈垦 朱雅丽 谢文瑞 叶东雯 张伟彬 |
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| 作者单位： | 1. 广东药科大学大学附属第二医院/广州新海医院消化内科, 广东 广州 510300; |
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| 基金项目： | 广东省医学科学技术研究基金(A2016406) |
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| 摘 要： | 目的 探讨补充益生菌对根除慢性胃炎患者幽门螺旋杆菌(Helicobacter pylori, Hp)的临床效果及其胃黏膜病理损伤转归的影响。 方法 收集2017年1月1日—2017年8月31日在广东药科大学附属第二医院确诊的慢性胃炎伴Hp感染患者104例，按随机数字表法将患者分为对照组和实验组，每组52例，对照组患者仅根除Hp，实验组患者予根除Hp同时补充益生菌治疗，对比分析2组患者干预前和干预6个月后的临床症状、胃镜下胃黏膜表现、Hp根除率以及胃黏膜病理变化(包括炎症、萎缩、肠化生和异型增生)情况。 结果 根除Hp对2组患者的临床症状和病理损伤均有不同程度的改善，但实验组患者的临床疗效和Hp根除率优于对照组(90.38% vs. 78.85%，P=0.036；90.38% vs. 75.00%，P=0.038)，实验组患者干预后胃黏膜病理总评分低于对照组(4.15±1.02 vs. 5.92±1.75，P＜0.05)，其中胃黏膜炎症和肠化生病理改善疗效显著优于对照组(0.87±0.12 vs. 1.46±0.37，P<0.05；1.27±0.45 vs. 1.81±0.58，P<0.05)。 结论 根除幽门螺旋杆菌能使大多数慢性胃炎患者临床获益，补充益生菌可有效提高患者的临床疗效和Hp根除率，并减轻胃黏膜的病理损伤。
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| 关 键 词： | 慢性胃炎 幽门螺旋杆菌 益生菌 肠化生 异型增生 |
| 收稿时间： | 2018-05-11 |
Effects of probiotics on eradication of Helicobacter pylori infection and subsequent pathological change of gastric mucosa |
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| Affiliation: | Department of Gastroenterology, the Second Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510300, China |
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| Abstract: | Objective To investigate the effect of probiotics supplementation on Helicobacter pylori eradication therapy and the outcome of gastric mucosal injury in patient with chronic gastritis. Methods One hundred and four cases of chronic gastritis with Hp infection in our hospital were collected and randomly divided into control group (n=52) and experimental group (n=52). The patients in control group received Hp eradication therapy, while the patients in experiment group were gave Hp eradication and probiotics supplement therapy. The pathological changes of gastric mucosa (including inflammation, atrophy, intestinal metaplasia and dysplasia), Hp eradication rate, gastric mucosa appearance under gastroscopy and clinical symptom were observed and compared before and after intervention for 6 months. Results To some extent, eradication of Hp improved the clinical symptom and the pathological damage of patients in two groups, but the clinical efficacy and Hp eradication rate in the experiment group were better than those in the control group (90.38% vs. 78.85%, P=0.036; 90.38% vs. 75.00%, P=0.038), and the total scores of gastric mucosal pathological change in experimental group was lower than that in the control group after intervention (4.15±1.02 vs. 5.92±1.75, P<0.05), the pathological effect of gastric mucosal inflammation and intestinal metaplasia were significantly improved in experimental group than that in the control group (0.87±0.12 vs. 1.46±0.37, P<0.05; 1.27±0.45 vs. 1.81±0.58, P<0.05). Conclusion The eradication of Helicobacter pylori infection may be benefit for most patients with chronic gastritis. Supplementation of probiotics can effectively raise the clinical efficacy and Hp eradication rate, and lessen the pathological injury of gastric mucosa of patients. |
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