| IL-9在结肠癌组织中的表达及其临床意义 |
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| 引用本文： | 王进,董晓强,朱新国,赵华,毛德利,赵鑫. IL-9在结肠癌组织中的表达及其临床意义[J]. 南方医科大学学报, 2018, 38(8): 943 |
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| 作者姓名： | 王进 董晓强 朱新国 赵华 毛德利 赵鑫 |
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| 摘 要： | 目的探讨IL-9在结肠癌组织中的表达水平及其临床意义。方法采用免疫组化法和实时荧光定量PCR（qRT-PCR）法分别检测92例结肠癌组织及相应癌旁正常组织中IL-9的表达情况；统计分析IL-9在结肠癌与癌旁正常组织中的表达差异；分析IL-9蛋白表达与结肠癌患者的临床病理特征及生存预后之间的关系。结果在癌旁正常组织中IL-9蛋白及mRNA的表达水平均显著高于结肠癌组织（P<0.001）。IL-9 蛋白表达水平与结肠癌患者的TNM分期、Ducks 分期及淋巴结转移相关（P=0.013,0.025, 0.004），而与性别、年龄、肿瘤大小、分化程度及肝转移等临床病理特征无明显相关性（P>0.05）。IL-9表达阳性结肠癌患者的生存时间明显长于阴性表达的患者（P=0.015）。结论IL-9在结肠癌组织中较在癌旁正常组织中低表达；IL-9在结肠癌组织中的表达与TNM分期、Ducks分期及淋巴结转移呈负相关，与良好预后呈正相关，提示在结肠癌肿瘤微环境中IL-9发挥了重要的作用。
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Expression of interleukin-9 in colon cancer tissues and its clinical significance |
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| Abstract: | Objective To investigate the expression of interleukin-9 (IL-9) in colon cancer tissues and its clinical significance.Methods Immunohistochenmistry and qRT-PCR were used to detect the expressions of IL-9 protein and mRNA in 92 coloncancer tissues and paired adjacent normal tissues. The correlation of IL-9 expressions with the clinicopathological features andprognosis of the patients was analyzed. Results IL-9 protein and mRNA expressions were significantly higher in adjacentnormal tissues than in the colon cancer tissues (P<0.001). In colon cancer patients, IL-9 expression was significantly correlatedwith TNM stage (P=0.013), Ducks stage (P=0.025) and lymph node metastasis (P=0.004) but not with gender, age, tumor size,differentiation or hepatic metastasis (P>0.05). The survival time of colon cancer patients with positive IL-9 expression wassignificantly longer than that of patients negative for IL-9 expression (P=0.015). Conclusions IL-9 expression is lowered incolon cancer tissues compoved with in the adjacent normal tissues. IL-9 expression is negatively correlated with TNM staging,Ducks staging and lymph node metastasis but positively with good prognosis, suggesting its important role in the tumormicroenvironment of colon cancer. |
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