Negative self-feedback induced enhancement and transition of spiking activity for class-3 excitability |
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| Affiliation: | 1.Guangdong Key Laboratory of Modern Control Technology, Institute of Intelligent Manufacturing, Guangdong Academy of Sciences, Guangzhou 510070, China;2.School of Science, Henan Institute of Technology, Xinxiang 453003, China;3.School of Aerospace Engineering and Applied Mechanics, Tongji University, Shanghai 200092, China |
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| Abstract: | Post-inhibitory rebound (PIR) spike, which has been widely observed in diverse nervous systems with different physiological functions and simulated in theoretical models with class-2 excitability, presents a counterintuitive nonlinear phenomenon in that the inhibitory effect can facilitate neural firing behavior. In this study, a PIR spike induced by inhibitory stimulation from the resting state corresponding to class-3 excitability that is not related to bifurcation is simulated in the Morris-Lecar neuron. Additionally, the inhibitory self-feedback mediated by an autapse with time delay can evoke tonic/repetitive spiking from phasic/transient spiking. The dynamical mechanism for the PIR spike and the tonic/repetitive spiking is acquired with the phase plane analysis and the shape of the quasi-separatrix curve. The result extends the counterintuitive phenomenon induced by inhibition to class-3 excitability, which presents a potential function of inhibitory autapse and class-3 neuron in many neuronal systems such as the auditory system. |
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| Keywords: | post-inhibitory rebound spike class 3 excitability inhibitory autapse neuronal firing |
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