| 靶向B细胞成熟抗原在多发性骨髓瘤中的治疗进展 |
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| 引用本文： | 刘佳慧,邱录贵,安刚. 靶向B细胞成熟抗原在多发性骨髓瘤中的治疗进展[J]. 中国肿瘤临床, 2022, 49(20): 1039-1046. DOI: 10.12354/j.issn.1000-8179.2022.20220104 |
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| 作者姓名： | 刘佳慧 邱录贵 安刚 |
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| 作者单位： | 中国医学科学院血液病医院（中国医学科学院血液学研究所），实验血液学国家重点实验室， 国家血液系统疾病临床学研究中心，细胞生态海河实验室（天津市300020） |
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| 基金项目： | 本文课题受国家自然科学基金国际（地区）合作与交流项目（编号:81920108006）资助 |
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| 摘 要： | 过去20年，多发性骨髓瘤（multiple myeloma，MM）的治疗取得了较大的进展，患者的生存时间获得显著延长，但多数患者最终仍会复发或变为难治性，MM仍然无法治愈。B细胞成熟抗原（B cell maturation antigen，BCMA）的表达仅限于一些B细胞谱系，在MM细胞上广泛表达，是MM的一个理想靶抗原。多种靶向BCMA的治疗，包括嵌合抗原受体（chimeric antigen receptor，CAR）T 细胞、双特异性抗体（bispecific antibodies，BsAbs）和抗体-药物偶联物（antibod-drug conjugate，ADC），在复发/难治性MM患者中取得显著的临床反应。本文综述了近年来MM靶向BCMA治疗的研究进展。
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| 关 键 词： | BCMA 多发性骨髓瘤 CAR-T细胞治疗 双特异性抗体 抗体药物偶联物 |
| 收稿时间： | 2022-01-19 |
Progress of immunotherapy targeting B cell maturation antigen for multiple myeloma |
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| Affiliation: | Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin 300020, China |
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| Abstract: | In the past two decades, considerable progress has been made in the treatment of multiple myeloma (MM). The survival of MM patients has been significantly prolonged. However, most patients eventually relapse or become refractory to treatment. Thus, MM remains incurable. The expression of B cell maturation antigen (BCMA) is limited to some B cell lineages (both normal and malignant plasma cells) and is widely expressed on MM cells. Thus, BCMA is an ideal target antigen for MM. A variety of therapies targeting BCMA, including chimeric antigen receptor (CAR) T cells, bispecific antibodies (BsAbs), and antibody-drug conjugates (ADCs), are currently in clinical trials in myeloma patients. Significant clinical responses have been achieved in patients with relapsed/refractory MM. This review summarizes the research progress of MM-targeted BCMA therapy in recent years. |
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