| 辛伐他汀联合维生素C对维持性血液透析患者微炎症反应的影响 |
| |
| 引用本文： | 张春红. 辛伐他汀联合维生素C对维持性血液透析患者微炎症反应的影响[J]. 矿产勘查, 2013, 0(11): 60-62,79 |
| |
| 作者姓名： | 张春红 |
| |
| 作者单位： | 泰兴市人民医院血液净化中心,江苏泰州225400 |
| |
| 摘 要： | 目的 探讨辛伐他汀联合维生素C对维持性血液透析（MHD）患者微炎症状态的影响.方法 将62例行MHD的慢性肾功能衰竭患者按随机数字表法分为2组：对照组31例给予维生素C治疗,观察组31例给予辛伐他汀联合维生素C治疗,疗程均为3个月.观察2组患者治疗前后血清炎症指标[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（hs-CRP）]、血脂指标[甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]、肾功能指标[血尿素氮（BUN）、血肌酐（Cr）]及营养指标[前白蛋白（PA）、转铁蛋白（TF）、血清白蛋白（ALB）]的变化情况.结果 2组患者治疗后营养指标ALB、PA及TF与治疗前相比均明显升高（P＜0.05）,炎症指标hs-CRP、IL-6及TNF-α与治疗前相比均明显降低（P＜0.05）,血脂指标TG、TC、HDL-C及LDL-C与治疗前相比均明显下降（P＜0.05）;观察组治疗后营养指标、炎症指标及血脂指标改善程度与对照组治疗后比较均更为明显（P＜0.05）.2组治疗前后及2组间肾功能指标BUN、Cr比较差异均无统计学意义（P〉0.05）.结论 辛伐他汀联合维生素C能有效地改善MHD患者微炎症反应,同时能改善患者营养状态.
|
| 关 键 词： | 辛伐他汀 维生素C 维持性血液透析 炎症因子 |
Effect of Simvastatin Combined with Vitamin C on Microinflammatory Response in Maintenance Hemodialysis Patients |
| |
| ZHANG Chun-hong. Effect of Simvastatin Combined with Vitamin C on Microinflammatory Response in Maintenance Hemodialysis Patients[J]. Mineral Exploration, 2013, 0(11): 60-62,79 |
| |
| Authors: | ZHANG Chun-hong |
| |
| Affiliation: | ZHANG Chun-hong (Blood Purification Center, Taixing People＇s Hospital, Taizhou 225400 ,China) |
| |
| Abstract: | Objective To investigate the effect of simvastatin combined with vitamin C on microinflammatory state in maintenance hemodialysis（MHD） patients. Methods Sixty-two MHD patients with chronic renal failure（CRF） were randomly treated with vitamin C alone（control group, n： 31） or in combination with simvastatin （observation group, n = 31） for 3 months. Serum inflammatory cytokines [interleukin-6 （IL-6）, tumor necrosis factor-a （TNF-a） and C-reactive protein （hs-CRP） 1, blood lipids [-triglycerides（TG）, total cholesterol （TC）, high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C）], renal function param- eters[blood urea nitrogen（BUN） and creatinine（Cr）] and nutrition indicators[-prealbumin （PA）, transferrin（TF） and albumin（ALB）] were measured before and after treatment. Results After treatment, levels of ALB, PA and TF increased but levels of hs-CRP, IL-6, TNF-a, TG, TC, HDL- C and LDL-C decreased in both groups（P〈0.05）. Moreover, the improvements in inflammatory cytokines, blood lipids and nutrition indicators in observation group were more obvious than those in control group（P〈0.05）. No obvious changes in levels of BUN and Cr were observed before and after treatment, and no significant the two groups（P〉0. 05）. Conclusion prove microinflammatory response and differences in levels of BUN and Cr were found between Simvastatin combined with vitamin C can effectively imnutritional status in MHD patients. |
| |
| Keywords: | simvastatin vitamin C maintenance hemodialysis inflammatory cytokines |
| 本文献已被 维普 等数据库收录！ |
|
