Strategy for Tuning the Photophysical Properties of Photosensitizers for Use in Photodynamic Therapy |
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| Authors: | Dr. Noureen Siraj Dr. Bishnu P. Regmi Prof. Dr. Isiah M. Warner |
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| Affiliation: | 1. Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 (USA)These authors contributed equally to the work.;2. Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 (USA) |
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| Abstract: | A novel approach for tuning spectral properties, as well as minimizing aggregation, in zinc porphyrin and zinc phthalocyanine‐based compounds is presented. Particular emphasis is placed on use of these compounds as photosensitizers in photodynamic therapy (PDT). To accomplish this aim, a bulky hydrophobic cation, trihexyltetradecylphosphonium, is paired with anionic porphyrin and phthalocyanine dyes to produce a group of uniform materials based on organic salts (GUMBOS) that absorb at longer wavelengths with high molar absorptivity and high photostability. Nanoparticles derived from these GUMBOS possess positively charged surfaces with high zeta potential values, which are highly desirable for PDT. Upon irradiation at longer wavelengths, these GUMBOS produced singlet oxygen with greater efficiency as compared to the respective parent dyes. |
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| Keywords: | GUMBOS nanoparticles photodynamic therapy phthalocyanine porphyrin singlet oxygen |
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