| 针刺蝶腭神经节治疗变应性鼻炎的多中心病例系列研究 |
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| 引用本文： | 针刺蝶腭神经节治疗变应性鼻炎的多中心病例系列研究. 针刺蝶腭神经节治疗变应性鼻炎的多中心病例系列研究[J]. 首都医科大学学报, 2019, 40(6): 916-920. DOI: 10.3969/j.issn.1006-7795.2019.06.019 |
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| 作者姓名： | 针刺蝶腭神经节治疗变应性鼻炎的多中心病例系列研究 |
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| 作者单位： | 1. 首都医科大学附属北京同仁医院针灸科, 北京 100010;2. 北京汇安中西医结合医院针灸科, 北京 100071;3. 北京市通州区中西医结合医院针灸科, 北京 101149;4. 北京市平谷区中医医院针灸科, 北京 101200;5. 北京市怀柔区中医医院针灸科, 北京 101400;6. 北京市朝阳区中医医院针灸科, 北京 100020;7. 首都医科大学附属复兴医院月坛社区卫生服务中心, 北京 100032 |
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| 基金项目： | 北京市优秀人才资助（青年骨干）项目（2014000021469G263），鼻病研究北京市重点实验室开放课题（2014BBYJ01）。 |
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| 摘 要： | 目的 初步评价针刺蝶腭神经节治疗变应性鼻炎（allergic rhinitis，AR）的临床疗效。方法 采用病例系列研究设计，自2017年4月至2018年6月分别于7个分中心纳入222例过敏性鼻炎患者予针刺蝶腭神经节治疗，各分中心之间纳入患者的基线一致，每周1次，共4次。分别于治疗前、治疗第2、3、4、8周进行鼻炎症状量表（total nasal symptom score，TNSS）和鼻炎伴随症状量表（total nonnasal symptom score，TNNSS）评价，于治疗前、治疗第4、8周进行鼻结膜炎生活质量调查问卷标准版（rhinconjunctivitis quality of life questionnaire，RQLQ）评价。结果 222例患者中有1例失访，纳入统计的有效量表分别为221份TNSS、218份TNNSS、213份RQLQ。患者TNSS量表和TNNSS量表评分自针刺第2周开始持续下降至第8周（治疗结束后4周，观察结束时点），RQLQ量表评分在第4周或此前即明显降低，并于第8周进一步下降，差异均具有统计学意义。1例患者出现面颊肿胀的轻微不良反应。在8周的观察期内，AR患者的控制率超过80%。结论 初步证明针刺蝶腭神经节治疗AR有效、安全、具备推广的可行性。进一步研究将增加客观指标评价、补充针刺即刻效应观察，细化可能的不良反应种类，延长随访时间，明确不同刺激方式对AR治疗效果的影响，规范针刺方案，优化患者就诊体验。
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| 关 键 词： | 蝶腭神经节 针刺疗法 变应性鼻炎 病例系列研究 中西医结合 |
| 收稿时间： | 2019-03-25 |
A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion |
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| Zhang Peng,Yang Wei,Wang Kuiji,Tan Yi,Shang Xiaojuan,Shu Ning,Wang Xiang,Xu Shiwen,Sun Sanfeng,Zhao Xinyu,Yu Kun,Chen Luquan. A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion[J]. Journal of Capital Medical University, 2019, 40(6): 916-920. DOI: 10.3969/j.issn.1006-7795.2019.06.019 |
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| Authors: | Zhang Peng Yang Wei Wang Kuiji Tan Yi Shang Xiaojuan Shu Ning Wang Xiang Xu Shiwen Sun Sanfeng Zhao Xinyu Yu Kun Chen Luquan |
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| Abstract: | Objective To evaluate the clinical efficacy of acupuncture on sphenopalatine ganglion in the treatment of allergic rhinitis (AR). Methods Totally 222 patients with allergic rhinitis were enrolled in 7 sub-centers from April 2017 to June 2018. The baseline of the patients was the same among the sub-centers, once a week for 4 times. Total nasal symptom score (TNSS) and total nonnasal symptom score (TNNSS) were evaluated before treatment, 2, 3, 4 and 8 weeks, respectively. Rhinconjunctivitis quality of life questionnaire (RQLQ) was evaluated before treatment, 4 and 8 weeks. Results One of 222 patients was lost to follow-up. Totally 221 TNSS, 218 TNNSS and 213 RQLQ were included in the effective scale. The scores of patients' TNSS scale and TNNSS scale decreased continuously from the 2nd week of acupuncture to the 8th week (4 weeks after the end of treatment, the end point of observation). The scores of RQLQ scale decreased significantly at the 4th week and continued to decrease to the 8th week. The differences were statistically significant. One patient had mild adverse reaction of cheek swelling. During the 8-week observation period, the control rate of AR patients exceeded 80%. Conclusion Acupuncture of sphenopalatine ganglion is effective, safe and can be popularized in the treatment of AR. Further research will increase objective index evaluation, supplement observation of immediate effect of acupuncture, refine the types of possible adverse reactions, prolong the follow-up time, clarify the effect of different stimulation methods on AR treatment effect, standardize the acupuncture program, and optimize the patient's treatment experience. |
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| Keywords: | sphenopalatine ganglion acupuncture therapy allergic rhinitis case series study integrated traditional Chinese and Western Medicine |
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