Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds |
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| Authors: | Dr. Suzanne J. F. Kaptein Dr. Paolo Vincetti Dr. Emmanuele Crespan Dr. Jorge I. Armijos Rivera Prof. Gabriele Costantino Dr. Giovanni Maga Prof. Johan Neyts Prof. Marco Radi |
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| Affiliation: | 1. Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium;2. Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy;3. National Research Council, Institute of Molecular Genetics IGM-CNR, Pavia, Italy |
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| Abstract: | Social and demographic changes across the world over the past 50 years have resulted in significant outbreaks of arboviruses such as dengue virus (DENV) and Zika virus (ZIKV). Despite the increased threat of infection, no approved drugs or fully protective vaccines are available to counteract the spread of DENV and ZIKV. The development of “broad‐spectrum” antivirals (BSAs) that target common components of multiple viruses can be a more effective strategy to limit the rapid emergence of viral pathogens than the classic “one‐bug/one‐drug” approach. Starting from previously identified multitarget DENV inhibitors, herein we report the identification of novel 2,6‐diaminopurine derivatives that are able to block the replication of both Zika virus and all serotypes of dengue virus (DENV 1–4) in infected cells. |
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| Keywords: | 2,6-diaminopurines broad-spectrum antivirals co-infections dengue zika |
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