Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene. |
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| Authors: | T Grimm, B Mü ller, M Dreier, E Kind, T Bettecken, G Meng, C R Mü ller |
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| Affiliation: | Institut für Humangenetik, Universität Würzburg, Federal Republic of Germany. |
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| Abstract: | The DMD gene, which spans more than 2,000 kbp, has been assigned to band Xp21 of the X chromosome. Two subclones (PERT 87-1 and PERT 87-15) of the intragenic locus DXS164 physically are separated by approximately 60 kbp. Linkage studies were done in 49 informative DMD families by using the LINKAGE program. Crossing-over between the loci studied occurred in four families. A recombination rate of 4% (support interval [Zmax-1] 1%-10%), which was 54 (support interval 14-135-fold) times higher than expected, was found with a maximum lod score of 13.50. These data suggest a hot spot for recombination within DXS164. |
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