NIR‐Triggered Synergic Photo‐chemothermal Therapy Delivered by Reduced Graphene Oxide/Carbon/Mesoporous Silica Nanocookies |
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| Authors: | Yu‐Wei Chen Po‐Jung Chen Shang‐Hsiu Hu I‐Wei Chen San‐Yuan Chen |
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| Affiliation: | 1. Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, Taiwan;2. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan;3. Department of Materials Sciences and Engineering, University of Pennsylvania, Philadelphia, PA, USA;4. Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan, R.O.C. |
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| Abstract: | A novel photo‐responsive drug carrier that doubles as a photothermal agent with a nanocookie‐like structure is constructed by coating amorphous carbon on a mesoporous silica support self‐assembled on a sheet of reduced graphene oxide. With a large payload (0.88 mmolg?1) of a hydrophobic anticancer drug, (S)‐(+)‐camptothecin (CPT), nanocookies simultaneously provide a burst‐like drug release and intense heat upon near‐infrared exposure. Being biocompatible yet with a high efficiency for cell uptake, nanocookies have successfully eradicated subcutaneous tumors in 14 days following a single 5 min NIR irradiation without distal damage. These results demonstrate that the nanocookie is an excellent new delivery platform for local, on‐demand, NIR‐responsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications. |
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| Keywords: | reduced graphene oxide carbon mesoporous silica chemotherapy hyperthermia nanocookies |
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