| IL-17F在口腔鳞状细胞癌患者血清中的表达及意义 |
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| 引用本文： | 李兵,傅尧,符义富,游丽萍,刘畅. IL-17F在口腔鳞状细胞癌患者血清中的表达及意义[J]. 现代检验医学杂志, 2016, 0(6): 77-78，81. DOI: 10.3969/j.issn.1671-7414.2016.06.021 |
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| 作者姓名： | 李兵 傅尧 符义富 游丽萍 刘畅 |
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| 作者单位： | 南京大学医学院附属口腔医院检验科,南京 210008 |
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| 摘 要： | 目的 探讨IL-17F(interleukin 17F)在口腔鳞状细胞癌(OSCC)患者血清中的表达及意义。方法 收集33例健康对照者、25例经病理证实为白斑的患者和80例OSCC患者的血清,用ELISA方法检测IL-17F的表达水平,分析其与临床病理参数的关系。结果 OSCC患者血清IL-17F水平为65.1±7.2 pg/ml,显著低于健康对照者(202.2±31.5 pg/ml)和白斑患者(168.2±17.4 pg/ml),差异均具有统计学意义(t=6.16,6.22,P<0.05),OSCC患者血清中IL-17F水平与TNM分期明显相关(P<0.05)。受试者工作特征曲线(ROC曲线)显示血清中IL-17F能够很好地区分健康人和OSCC患者(P<0.05),其最佳临界值为37.8 pg/ml。结论 OSCC患者血清中IL-17F的表达降低,提示其可能与肿瘤发生、发展相关。
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| 关 键 词： | IL-17F 口腔鳞状细胞癌 血清 筛查指标 |
Expression of Interleukin 17F in Serum of Oral Squamous CellCarcinoma Patients and Its Clinic Significance |
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| LI Bing,FU Yao,FU Yi-fu,YOU Li-ping,LIU Chang. Expression of Interleukin 17F in Serum of Oral Squamous CellCarcinoma Patients and Its Clinic Significance[J]. Journal of Modern Laboratory Medicine, 2016, 0(6): 77-78，81. DOI: 10.3969/j.issn.1671-7414.2016.06.021 |
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| Authors: | LI Bing FU Yao FU Yi-fu YOU Li-ping LIU Chang |
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| Affiliation: | Department of Clinical Laboratory,Affilioted NanjingStomatological Hospital,Nanjing University Medical School,Nanjing 210008,China |
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| Abstract: | Objective This study focus on the serum expression of IL-17F(interleukin 17F)and its' clinical diagnostic value for normal,leukoplakia patient and Oral Squamous Cell Carcinoma(OSCC)serum specimens.Methods The concentration of IL-17F in the serum was assessed by ELISA in healthy donors(n=33),leukoplakia patients(n=25)andOSCC patients(n=80).Results IL-17F concentrationwas lower in OSCC patients than in healthy donors and leukoplakia patients(65.1 pg/ml vs 202.2 pg/ml or 168.2 pg/ml,t=6.16,6.22,P<0.05).The expression of IL-17F was positively associated to TNM stage in OSCC(P<0.05).The receiver operating characteristic(ROC)curve suggests that IL-17F in serum was a good diagnostic marker to discriminate healthy people from leukoplakiapatients,the cutoff values was 37.8 pg/ml.Conclusion The expression of IL-17F in serum correlated to OSCC progression and could be a potential diagnostic biomarker for oral disease. |
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