| GP73在HBV相关性肝病中的水平及意义 |
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| 引用本文： | 胡善雷,李广明,任 娜,许金生,高 鹏,李 琤. GP73在HBV相关性肝病中的水平及意义[J]. 天津医科大学学报, 2019, 0(6): 615-617 |
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| 作者姓名： | 胡善雷 李广明 任 娜 许金生 高 鹏 李 琤 |
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| 作者单位： | （郑州市第六人民医院肝病科，郑州 450000） |
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| 摘 要： | 目的:探讨高尔基体蛋白73（GP73）在乙型肝炎病毒（HBV）相关性肝病中的检测及意义。方法:选取2016年5月-2018年5月在我院治疗的HBV相关性肝病患者160例，其中慢性乙肝患者78例，乙肝肝硬化患者52例，肝癌患者30例，采用GP73检测试剂盒检测血清GP73水平。结果:肝癌组、乙肝肝硬化组和慢性乙肝组血清GP73分别为（101.11±35.60）ng/mL、（81.87±30.54）ng/mL和（60.45±12.24）ng/mL，肝癌组＞乙肝肝硬化组＞慢性乙肝组＞对照组（P＜0.05）；丙氨酸氨基转移酶（ALT）、天门冬氨酸转氨酶（AST）和总胆红素（TBIL）水平，肝癌组＞乙肝肝硬化组＞慢性乙肝组＞对照组（P＜0.05），而ALB水平，肝癌组＜乙肝肝硬化组＜慢性乙肝组＜对照组（P＜0.05）；血清GP73与ALT、AST、TBIL成正相关（r=0.451、0.406和0.357，P＜0.05），与ALB成负相关（r=-0.380，P＜0.05）。结论: GP73在HBV相关性肝病中明显升高，与疾病严重程度和肝功能有一定关系。
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| 关 键 词： | 高尔基体蛋白73 乙型肝炎病毒 肝癌 肝硬化 |
The level and significance of GP73 in HBV related liver diseases |
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| HU Shan-lei,LI Guang-ming,REN Na,XU Jing-sheng,GAO Peng,LI Zheng. The level and significance of GP73 in HBV related liver diseases[J]. Journal of Tianjin Medical University, 2019, 0(6): 615-617 |
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| Authors: | HU Shan-lei LI Guang-ming REN Na XU Jing-sheng GAO Peng LI Zheng |
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| Affiliation: | （Depratment of Hepatology ，The Sixth People’s Hospital of Zhengzhou，Zhengzhou 450000，China） |
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| Abstract: | Objective: To investigate the detection and significance of Golgi protein 73 (GP73) in hepatitis B virus (HBV) related liver diseases. Methods: From May 2016 to May 2018,160 patients with HBV-related liver diseases were selected, including 78 patients with chronic hepatitis B, 52 patients with cirrhosis of hepatitis B and 30 patients with hepatocellular carcinoma, the serum GP73 level was detected by GP73 test kit. Results: The serum GP73 levels in hepatocellular carcinoma group, hepatitis B cirrhosis group and chronic hepatitis B group were (101.11±35.60) ng/mL, (81.87±30.54) ng/mL and (60.45±12.24) ng/mL, the serum GP73 levels in hepatocellular carcinoma group＞ hepatitis B cirrhosis group＞chronic hepatitis B group＞control group (P<0.05);alanineaminotransferase(ALT),aspartate aminotransferase (AST) and tumor bilirubin(TBIL) in hepatocellular carcinoma group＞hepatitis B cirrhosis group＞chronic hepatitis B group＞control group (P＜0.05), and ALB in hepatocellular carcinoma group＜hepatitis B cirrhosis group＜chronic hepatitis B group＜control group (P＜0.05); serum GP73 were positively correlated with ALT, AST and TBIL (r=0.451, 0.406 and 0.357, P＜0.05), and negatively correlated with ALB (r=-0.380, P＜0.05). Conclusion: GP73 are increased significantly in HBV related liver diseases, which are related to the severity of disease and liver function. |
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| Keywords: | Golgi protein 73 hepatitis B virus liver cancer cirrhosis |
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