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伴有食管外症状的反流性食管炎患者的危险因素分析
引用本文:王荣欣,王晶,胡水清. 伴有食管外症状的反流性食管炎患者的危险因素分析[J]. 首都医科大学学报, 2022, 43(1): 132-137. DOI: 10.3969/j.issn.1006-7795.2022.01.022]
作者姓名:王荣欣  王晶  胡水清
作者单位:1.首都医科大学宣武医院急诊科,北京 100053;2.首都医科大学宣武医院消化科,北京 100053
摘    要:目的 通过对伴有和不伴有食管外(extra-esophageal,EE)症状的反流性食管炎(reflux esophagitis,RE)患者的一般人口学资料、生活方式、饮食习惯、合并症、目前用药、焦虑、抑郁等方面的比较,探讨EE症状发生的危险因素.方法 选取2016年9月到2017年8月于首都医科大学宣武医院消化科门诊...

关 键 词:反流性食管炎  食管外症状  焦虑  抑郁  危险因素
收稿时间:2021-09-04

Analysis of risk factors in patients with reflux esophagitis with extra-esophageal symptoms
Wang Rongxin,Wang Jing,Hu Shuiqing. Analysis of risk factors in patients with reflux esophagitis with extra-esophageal symptoms[J]. Journal of Capital Medical University, 2022, 43(1): 132-137. DOI: 10.3969/j.issn.1006-7795.2022.01.022]
Authors:Wang Rongxin  Wang Jing  Hu Shuiqing
Affiliation:1. Emergency Department, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;2. Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Abstract:Objective To determine the risk factors of the reflux esophagitis (RE) with extra-esophageal(EE)symptoms by comparing general demographic information, lifestyle, eating habits, comorbidities, current medications, anxiety, depression of RE patients with and without EE symptoms. Methods The subjects of the study were seen in the Department of Gastroenterology, Xuanwu Hospital, Capital Medical University from September 2016 to August 2017 and were clearly diagnosed as RE under gastroscopy. There were 361 cases in total. They were divided into group with EE symptoms and group without EE symptoms. The patients were surveyed on General demographic information, lifestyle, eating habits, comorbidities, current medications, Patient Health Questionnaire-9(PHQ-9) Depression Scale, General Anxiety Disorder-7(GAD-7) Anxiety Scale, Gastroesophageal Reflux Disease Questionnaire(GerdQ)and Reflux Symptom Index(RSI). Results Among the 361 patients with RE, there were 218 patients with EE symptoms. Sensation of foreign body within the throat, recurrent sore throat and chronic cough were more common, accounting for 52.75%, 46.79% and 26.15% respectively. Univariate analysis showed that there were significant differences in low education level, smoking, constipation, high body mass index (BMI), anxiety, and depression (P<0.05) between two groups. Multivariate Logistic regression analysis identified that low education level (OR:1.646, 95%CI:1.049-2.572,P<0.05), smoking (OR:2.488,95%CI: 2.047-3.281, P<0.01), high BMI (OR:1.067, 95%CI: 1.004-1.135, P<0.05), depression (OR: 1.062, 95%CI: 1.002-1.133, P<0.05), anxiety(OR: 1.061, 95%CI: 1.001-1.131, P<0.05) were the risk factors of onset of EE symptoms in RE patients. Conclusion The main extra-esophageal symptoms of RE were sensation of foreign body within the throat and recurrent sore throat, chronic cough. Low education level, high BMI, smoking, depression and anxiety were risk factors of RE with extra-esophageal symptoms.
Keywords:reflux esophagitis  extra-esophageal symptoms  depression  anxiety  risk factors  
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