MAC与EMA-CO方案治疗妊娠滋养细胞肿瘤肺转移的疗效对比分析
《现代肿瘤医学》[ISSN:1672-4992/CN:61-1415/R]
- 期数:
- 2016年02期
- 页码:
- 291-294
- 栏目:
- 论著（妇科肿瘤）
- 出版日期:
- 2015-12-08
文章信息/Info
- Title:
- Clinical research gestational trophoblastic tumor lung metastases
- Author(s):
- Chen Yali; Xu Yili
- Department of Obstetrical,Wuhan First Maternity Hospital,Hubei Wuhan 430030,China.
- 关键词:
- 妊娠滋养细胞肿瘤肺转移; MAC方案; EMA-CO方案
- Keywords:
- gestational trophoblastic tumor lung metastasis; MAC; EMA-CO
- 分类号:
- R737.33
- DOI:
- 10.3969/j.issn.1672-4992.2016.02.037
- 文献标识码:
- A
- 摘要:
- 目的:对比评价两方案（MAC方案与EMA-CO方案）治疗妊娠滋养细胞肿瘤肺转移的疗效和毒副反应,以期为妊娠滋养细胞肿瘤肺转移化疗提供借鉴。方法:选择2009年6月至2013年12月的妊娠滋养细胞肿瘤肺转移患者124例作为研究对象，采用随机数字表法将其随机分为两组：治疗组和对照组，对照组予以EMA-CO方案治疗，治疗组MAC方案治疗，观察其疗效和副反应评价。结果:MAC方案组与EMA-CO方案组治疗妊娠滋养细胞肿瘤肺转移的完全缓解率分别为76.67%和71.88%,有效率分别为96.67%和100%；完全缓解率及有效率的比较经χ2检验，P＞0.05，差异无显著性意义，MAC方案低危型CR率明显高于EMA-CO方案，高危型CR率低于EMA-CO方案，组间比较差异均有统计学意义；MAC方案组血HCG降至正常时间及总疗程均较EMA-CO方案组少。两组患者恶心呕吐发生率、肝肾损伤发生率比较，P＞0.05,在统计学上无明显差异；但MAC组的骨髓抑制发生率和肝肾损伤发生率、严重程度及腹泻发生率、口腔溃疡发生率均低于EMA-CO组，P均<0.05,差异有统计学意义。另外，MAC方案组的复发率、平均住院日、化疗时间、费用等指标均较EMA-CO方案组少。结论：采用MAC方案治疗妊娠滋养细胞肿瘤肺转移的总体疗效与EMA-CO方案相当，MAC组重度骨髓抑制、胃肠道反应及口腔溃疡的发生明显少于EMA-CO组,并且疗程短,化疗时间及费用少,复发率低,患者更易于接受,依从性好,可以作为临床一线用药进一步推广。
- Abstract:
- Objective:Comparative two treatments of gestational trophoblastic efficacy and toxicity with tumor lung metastases.Methods:All 124 patients with lung metastases were randomly divided into two groups,the treatment group and the control group.The control group was given EMA-CO regimen,the treatment group MAC regimen.Results:MAC program group and EMA-CO regimen treatment of gestational trophoblastic tumor complete response rate of pulmonary metastasis were 76.67% and 71.88%,effective rate was 96.67% and 100%,respectively.P＞ 0.05,the difference was not statistically significant in two groups.FIGO prognostic score low risk and high-risk CR rate and CR + PR rate differences were statistically significant,MAC scheme CR rate was significantly low risk higher than EMA-CO program,high-risk CR rate lower than EMA-CO program,there were significant differences between the groups.Two groups of patients the incidence of nausea and vomiting,the incidence of liver and kidney damage,P＞ 0.05,no statistically significant difference.MAC croup marrow suppression and kidney injury incidence rate and severity,the incidence of diarrhea,mouth ulcers were lower than EMA-CO group,P＜0.05.Conclusion:MAC regimen gestational trophoblastic tumor lung metastases overall efficacy and EMA-CO program fairly,MAC group and severe bone marrow suppression,gastrointestinal reactions and oral ulcers was significantly less than the EMA-CO group,and short course chemotherapy time and cost less,recurrence rate.
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备注/Memo
- 备注/Memo:
- 武汉市卫生局临床重点专科科研项目（编号：10C01）
