| 新型抗脑缺血海洋新药989对血栓性大鼠脑缺血的保护作用 |
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| 引用本文： | 戚欣,耿美玉,辛现良,管华诗.新型抗脑缺血海洋新药989对血栓性大鼠脑缺血的保护作用[J].中国海洋大学学报(自然科学版),2001,31(3):356-360. |
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| 作者姓名： | 戚欣 耿美玉 辛现良 管华诗 |
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| 作者单位： | 青岛海洋大学海洋药物与食品研究所, |
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| 基金项目： | 国家“九五”攻关资助课题!(96 - CO2 - 0 4- 0 1)资助 |
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| 摘 要： | 该文采用 Fe Cl3局部涂抹损伤血管造成的大鼠大脑中动脉血栓模型 ,以脑梗塞范围、行为障碍、脑组织病理改变为观察指标 ,研究 989对脑血栓所致局部缺血性脑损伤的保护作用。结果表明 :9895.0、10 .0 mg/ kg手术后 30 min舌下静脉注射能明显缩小脑栓塞大鼠 2 4 h后的脑梗塞范围 ;98910 .0 mg/ kg能明显改善脑栓塞大鼠的行为障碍。脑组织病理检查发现 ;98910 .0 mg/ kg组动物大脑中动脉内血栓形成极少或未形成 ,脑组织缺血病变较轻。表明 989对栓塞性脑损伤具有明显的保护作用
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| 关 键 词： | 989 脑栓塞 大鼠 硫酸多糖 |
| 文章编号： | 1001-1862(2001)03-356-05 |
| 修稿时间： | 2000年6月19日 |
Study on the Protective Effect of a New Type Anti-Cerebral Ischemia Marine Drug 989 on the Cerebral Ischemia of Rats |
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| Qi Xin,Geng Meiyu,Xin Xianliang,GUAN Huashi.Study on the Protective Effect of a New Type Anti-Cerebral Ischemia Marine Drug 989 on the Cerebral Ischemia of Rats[J].Periodical of Ocean University of China,2001,31(3):356-360. |
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| Authors: | Qi Xin Geng Meiyu Xin Xianliang GUAN Huashi |
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| Abstract: | The protective effects of 989 on cerebral ischemia induced by FeCl 3 in rats with cerebral middle artery (CMA) occlusion were investigated in this study. The results showed that 989 at a doses of 5.0 and 10.0 mg/kg via sublingular vein injection decreased the cerebral infarction area and 989 at a dose of 10.0 mg/kg improved the disbalance of behavior. Also, a significant difference existed between 989- treated group at the dose of 10.0 mg/kg and the FeCl 3 treated group on inhibiting the thrombosis embolic in CMA(p<0.01). Our data suggested that 989 exerted a protective action on cerebral ischemia induced by thrombosis in rats. |
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| Keywords: | 989 cerebral thrombosis rat sulfated polysaccharide |
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