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| mlc 1f 基因C2159G 多态性与中国北方汉族男性心脏结构和有氧运动能力的关联 | |
| 引用本文： | 文立,王佃鹏,吴志毅,曹红,席翼,张勇,胡扬.mlc 1f 基因C2159G 多态性与中国北方汉族男性心脏结构和有氧运动能力的关联[J].天津体育学院学报,2008,23(2):113-115. |
| 作者姓名： | 文立 王佃鹏 吴志毅 曹红 席翼 张勇 胡扬 |
| 作者单位： | 1. 天津体育学院运动人体科学系,天津,300381 2. 天津体育学院研究生部,天津,300381 3. 北京体育大学运动人体科学学院,北京,100084 |
| 摘 要： | 目的:探讨肌球蛋白轻链1f(Myosin light chain,1 fast;MLC 1f)基因多态性与中国北方平原地区汉族男性有氧运动能力及心脏结构的关联性.方法:102名无训练史的健康男子测试最大摄氧量(VO2max),超声心动测量左心室结构.PCR-RFLP分析mlc 1f的C2159G多态性.单因素方差分析检验C2159G多态性与心肌结构、功能及有氧运动能力的关联.结果:C2159G基因型频率为:CC=0.09,CG=O.60,GG=0.31;C2159G多态性与VO2max无显著相关,只有CC,基因型显著大于CC(P<0.05);C2159G与心脏结构和功能有关联,ESD、EDD、50W/SV、100W/SV指标CG、GG均显著(P<05)大于CC.结果提示C2159G基因多态性与心脏结构和功能相关. |
| 关 键 词： | MLC mlc 1f 基因多态性 心脏结构和功能 耐力运动能力 基因型频率 基因多态性 中国 北方汉族 男性 心脏结构和功能 有氧运动能力 关联性 Northern Part of China Han Nationality Capacity Endurance Ventricle Lift Structure Polymorphism 功能相关 指标 结果 心肌结构 |
| 文章编号： | 1005-0000(2008)02-0113-03 |
| 修稿时间： | 2008年1月13日 |
The Association of mlc 1f C2159G Polymorphism with Structure of Lift Ventricle and Endurance Capacity in Men of Han Nationality from Northern Part of China |
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| WEN Li,WANG Dianpeng,WU Zhiyi,CAO Hong,XI Yi,ZHANG Yong,HU Yang.The Association of mlc 1f C2159G Polymorphism with Structure of Lift Ventricle and Endurance Capacity in Men of Han Nationality from Northern Part of China[J].Journal of Tianjin Institute of Physical Education,2008,23(2):113-115. | |
| Authors: | WEN Li WANG Dianpeng WU Zhiyi CAO Hong XI Yi ZHANG Yong HU Yang |
| Affiliation: | Dept. of Exercise & Health Science, Tianjin Sport University, Tianjin 300381, China;Dept. of Exercise & Health Science, Tianjin Sport University, Tianjin 300381, China;Dept. of Exercise & Health Science, Tianjin Sport University, Tianjin 300381, China;Dept. of Postgraduate, Tianjin Sport University, Tianjin 300381, China;Dept. of Postgraduate, Tianjin Sport University, Tianjin 300381, China;Dept. of Postgraduate, Tianjin Sport University, Tianjin 300381, China;School of Exercise & Health Science, Beijing Sport University, Beijing 100084, China |
| Abstract: | Objective: To explore the associations of mlc 1f gene C2159G polymorphism with heart structure, function and endurance capacity. Methods: A group of 102 healthy untrained men from Northern part of China were employed in this study. VO2max and the structure of lift ventricle were measured. The genotypes were examined in mlc 1f C2159G by PCR - RFLP. Results: The genotype frequencies were as follows: CC=0.09, CG=0.60, GG=0.31. The polymorphism of C2159G didn't correlated with VO2max, CG genotype higher than CC significantly (p<0.05) only. The association between cardiac structure and function with C2159G were observed, ESD, EDD, 50W/SV, 100W/SV in CG and GG were greater than CC (p<0.05). These results support a positive association of C2159G with heart structure and function. |
| Keywords: | MLC mlc 1f gene polymorphism cardiac structure and function endurance capacity |
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