右美托咪定复合七氟醚在脑胶质瘤手术患者中的应用

目的观察右美托咪定复合七氟醚在脑胶质瘤术中的应用价值。方法选择郑州市第九人民医院2018-01-2020-01收治的76例脑胶质瘤患者为研究对象,随机数表法分为对照组和观察组各38例。对照组采用芬太尼复合七氟醚麻醉,观察组在对照组基础上采用右美托咪定麻醉。分别于术前1 d、术后1 d、术后3 d采用美国国立卫生研究院脑卒中量表(NIHSS)评估2组神经功能;分别于入室时(T0)、切开硬脑膜时(T2)及术毕时(T3)检测2组血清INOS及PI3K水平;记录2组用药不良反应。结果观察组术后1 d、3 d时的NIHSS评分均低于对照组,差异有统计学意义(P<0.05);2组T2时的INOS及PI3K水平均较T0、T1时升高,而观察组T2时的INOS及PI3K水平均低于对照组,差异有统计学意义(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论脑胶质瘤术中应用右美托咪定复合七氟醚麻醉安全性好,且可保护患者神经功能,减轻术中脑损伤。

Application of dexmedetomidine combined with sevoflurane in patients with glioma surgery

Objective To observe the application value of dexmedetomidine combined with sevoflurane in glioma surgery,mainly to observe the neurological function,serum inducible nitric oxide synthase(IN0S)and phosphatidylinositol 3-kinase(PI3K)levels of patients,to guide the reasonable anesthesia in glioma surgery in the future.Methods A total of 76 patients with glioma treated in the hospital from January 2018 to January 2020 were selected.According to the random number table method,they were di?vided into a control group and an observation group,each with 38 cases.The control group was anesthetized with fentanyl combined with sevoflurane,and the observation group was anesthetized with dexmedetomidine on the basis of the control group.One day before operation,1 day after operation,and 3 days after operation,the National Institutes of Health stroke scale(NIHSS)was used to eval?uate the neurological function between the two groups;at the time of entrance(T0)and the hard incision meningeal time(T2)and end of surgery(T3),detected the serum INOS and PI3K levels of the two groups;recorded the adverse reactions of the two groups.Results The NIHSS scores of the observation group 1 day and 3 days after operation were lower than those of the control group,and the difference was statistically significant(P<0.05);the levels of INOS and PI3K at T2 of the two groups were higher than those at T0 and T1,while the levels of INOS and PI3K at T2 of the observation group were lower than those of the control group,the differ?ence was statistically significant(P<0.05);compared the incidence of adverse reactions between the two groups,the difference was statistically significant(P>0.05).Conclusion Intraoperative dexmedetomidine combined with sevoflurane anesthesia has high safe?ty,and it can protect patients’neurological function and reduce intraoperative brain injury,which is worthy of clinical application.