| 脑脊液中检测DLL1对结核性脑膜炎的诊断意义 |
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| 引用本文： | 沈萍,鲁晶晶,李尽义,彭涛,贾延劼.脑脊液中检测DLL1对结核性脑膜炎的诊断意义[J].中国实用神经疾病杂志,2011,14(9):14-16. |
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| 作者姓名： | 沈萍 鲁晶晶 李尽义 彭涛 贾延劼 |
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| 作者单位： | 1. 河南新郑市人民医院神经内科,新郑,451100
2. 郑州大学第一附属医院神经内科,郑州,450052 |
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| 摘 要： | 目的探索脑脊液(CSF)中Delta-like-1(DLL1)的检测在结核性脑膜炎诊断中的临床价值。方法选择诊断明确的中枢神经系统感染性疾病患者50例,分为结核性脑膜炎(结脑组)30例,病毒性脑(膜)炎(病脑组)20例,以及正常对照组20例,颅内转移瘤(肿瘤组)8例。采用酶联免疫吸附试验定量测定患者CSF中DLL1的含量。结果各组CSF中DLL1的含量,结脑组显著高于其他组别,差异均有统计学意义(P<0.01),其他组别之间相比差异均无统计学意义(P>0.05)。各组CSF中DLL1的含量与CSF蛋白、细胞数、葡萄糖、氯化物及颅内压均无相关性。结论 DLL1检测作为一种新的指标,在结核性脑膜炎的诊断中可能有重要临床价值。
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| 关 键 词： | Delta-like-1 结核性脑膜炎 脑脊液 |
Significance of detecting DLL1 in cerebrospinal fluid on diagnosing tuberculous meningitis |
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| Shen Ping,Lu Jingjing,Li Jinyi,et al..Significance of detecting DLL1 in cerebrospinal fluid on diagnosing tuberculous meningitis[J].Chinese Journal of Practical Neruous Diseases,2011,14(9):14-16. |
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| Authors: | Shen Ping Lu Jingjing Li Jinyi |
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| Affiliation: | Shen Ping,Lu Jingjing,Li Jinyi,et al.Department of Neurology,the People's Hospital of Xinzheng City,Xinzheng 451100,China |
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| Abstract: | Objective To investigate clinical value of measurement of the cerebrospinal fluid DLL1 in diagnosis of tuberculous meningitis.Methods Fifty patients with central nervous system infects of explicit diagnosis were divided into two groups,group TM included 30 tuberculous meningitis sick patients,group VM included 20 viral meningitis cases,compared with 20 controls with no central nervous system infection,and group IMT included 8 intracranial metastatic tumors patients.Soluble DLL1 in CSF of these patients were... |
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| Keywords: | Delta-like-1 |
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