Organization of TNIK in dendritic spines |
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| Authors: | Alain C Burette Kristen D Phend Susan Burette Qingcong Lin Musen Liang Gretchen Foltz Noël Taylor Qi Wang Nicholas J Brandon Brian Bates Michael D Ehlers Richard J Weinberg |
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| Affiliation: | 1. Department of Cell Biology & Physiology, University of North Carolina, North Carolina;2. Shenogen Pharma Group, Beijing, People's Republic of China 102206;3. Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Andover, Massachusetts 01810;4. Clinical Research Unit, Pfizer, New Haven, Connecticut 06511;5. Biomarker and Personalized Medicine Group, Eisai Product Creation Systems, Eisai, Andover, Massachusetts 01810;6. Neuroscience Research Unit, Cambridge, Massachusetts 02139;7. AstraZeneca Neuroscience IMED, Cambridge, Massachusetts 02139;8. Centers for Therapeutic Innovation, Boston, Massachusetts 02115;9. Neuroscience Center, University of North Carolina, North Carolina |
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| Abstract: | Tumor necrosis factor receptor‐associated factor 2 (TRAF2)‐ and noncatalytic region of tyrosine kinase (NCK)‐interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high‐resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling. J. Comp. Neurol. 523:1913–1924, 2015 © 2015 Wiley Periodicals, Inc. |
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| Keywords: | TNIK dendritic spine PSD cerebral cortex striatum RRID:AB_11212843 RRID:AB_1858225 RRID:AB_11213019 RRID:nif‐0000– 30467 RRID:AB_94396 |
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