| 重型颅脑外伤患者血清MicroRNA765的表达与预后的研究 |
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| 引用本文： | 秦国强,黄卫民,彭才祖,施波,王冠严,程芬,王淳良.重型颅脑外伤患者血清MicroRNA765的表达与预后的研究[J].临床神经外科杂志,2014(5):367-370. |
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| 作者姓名： | 秦国强 黄卫民 彭才祖 施波 王冠严 程芬 王淳良 |
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| 作者单位： | 1. 广东医学院附属高明人民医院神经外科, 佛山,528500
2. 南昌大学第一附属医院神经外科 |
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| 摘 要： | 目的检测血清MicroRNA765(miR-765)的表达与重型颅脑外伤(sTBI)患者预后的关系。方法应用实时定量PCR检测健康对照组(CTL)、sTBI组监测患者伤后第1、4、7天血清miR-765水平。结果sTBI组血清miR-765表达水平相对CTL组有显著改变(P0.05),患者miR-765第一天开始上升,第4天达峰值水平,第7天明显下降,并与脑外伤后6个月GOS评分显著负相关,也与入院时GCS评分负相关。结论sTBI患者血清miR-765z早期变化可以作为评价患者预后的重要生化指标之一。
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| 关 键 词： | 重型颅脑外伤 miR-765 预后 |
Relation of prognosis and expression levels of miR-765 in serum for patients with severe traumatic brain injury |
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| Affiliation: | QIN Guo-qiang, HUANG Wei-ming, PENG Cai-zu, et al.( Department of Neurosurgery, the Affiliated Gaoming People＇s Hospital of Guangdong Medical College, Foshan 528500, China) |
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| Abstract: | Objective To investigate the dynamic change of expression levels of miR-765 and evaluate the prognostic value in in severe traumatic brain injury （ sTBI ） .Method Blood samples were collected from patients with sTBI and healthy subjects .Expression levels of miR-765 were detected by real-time PCR at 1 , 4 , 7 days after injury .Results It was significantly expression levels of miR-765 in serum between sTBI and CTL group （ P〈0.05） , expression levels of miR-765 in serum increased to the peak at 7 days and was significantly negatively correlated with GOS scores after 6 months of injury in sTBI group .Expression levels of miR-765 was also negatively correlated with GCS score at 1 day after injury .Conlusion Plasma miR-765 has strong potential as novel biomarkers for evaluating the patient＇s condition and prognosis with sTBI. |
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| Keywords: | severe traumatic brain miR-765 prognosis |
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