| 脑活素治疗血管性痴呆对照研究 |
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| 引用本文： | 肖世富,姚培芬.脑活素治疗血管性痴呆对照研究[J].临床精神医学杂志,1999,9(1):1-3. |
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| 作者姓名： | 肖世富 姚培芬 |
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| 作者单位： | 上海市精神卫生中心，中国人民解放军３０１医院，华西医科大学，北京安定医院，广州精神病医院，北京天坛医院，上海第二医科大学 |
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| 基金项目： | 卫生部药政局课题,奥地利依比威药厂资助 |
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| 摘 要： | 目的；验证脑活素治疗血管性痴呆的疗效。方法：为多中心双盲随机平行对照研究。脑活素与安慰剂的剂量均为１００ｍｌ的注射剂，安慰剂为生理盐水，研究药含３０毫升脑活素。治疗方法静脉滴注，共４周２０次。结果；共入组并完成观察１４７例ＶＤ病人，脑活素组和安慰剂对照组分别为７５例和７２例。治疗４周后，脑活素组简明智力检查量表平均总分比治疗前提高了２．７分，两组具有显著性差异。
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| 关 键 词： | 血管性痴呆 脑活素 药物疗法 |
A multi centre,double blind,placebo controlled trial of the efficacy of cerebrolysin in treatment of vascular dementia |
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| Xiao Shifu,Yan Heqin,Yao Peifen,et al..A multi centre,double blind,placebo controlled trial of the efficacy of cerebrolysin in treatment of vascular dementia[J].Journal of Clinical Psychological Medicine,1999,9(1):1-3. |
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| Authors: | Xiao Shifu Yan Heqin Yao Peifen |
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| Affiliation: | Xiao Shifu,Yan Heqin,Yao Peifen,et al.Shanghai Mental Health Centre,Shanghai 200030 |
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| Abstract: | Objective:To evaluate the efficacy of cerebrolysin in the treatment of mild to moderately severe vascular dementia. Method:The study involved a multi centre,double blind and paralled group design trial.A total of 147 patients age 55 to 85 suffering from mild to moderately severe vascular dementia were randomised to treatment with either 30ml cerebrolysin (75 subjects) or placcbo normal saline (72 subjects) iv drip once daily for four weeks. Results:Patients treated with cerebrolysin showed significantly more improvement in the MMSE scores and ZYT test over the placebo group.There was increase of 2 7 points in the MMSE over the baseline with the cerebrolysin group.The incidence of adverse side effects was low and comparable to the placebo group. Conclusion:Cerebrolysin is effective in the treatment of vascular dementia with rapid clinical response and few side effects. |
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| Keywords: | Cerebrolysin Vascular dementia |
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