| CASPR2/LGI1抗体双阳性女性Morvan综合征(附1例报告及文献复习) |
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| 引用本文： | 孙健,朱雯华,罗苏珊,乔凯,卢家红,赵重波.CASPR2/LGI1抗体双阳性女性Morvan综合征(附1例报告及文献复习)[J].中国临床神经科学,2019(3):273-280. |
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| 作者姓名： | 孙健 朱雯华 罗苏珊 乔凯 卢家红 赵重波 |
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| 作者单位： | 复旦大学附属华山医院神经内科 |
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| 摘 要： | 目的提高对接触蛋白相关样蛋白2(CASPR2)/富亮氨酸胶质瘤失活蛋白1(LGI1)抗体双阳性Morvan综合征的认识。方法收集诊治的1例CASPR2/LGI1抗体双阳性的女性Morvan综合征患者的临床资料,总结其诊疗经过、临床特点,结合文献复习予以分析讨论。结果患者女性,41岁,因四肢酸痛伴明显肉跳1个月就诊。病程中有出汗、血压波动、烦躁、睡眠障碍、低钠血症的临床表现。肌电图示肌颤搐电位,实验室检查血清CASPR2/LGI1抗体双阳性,因而确诊为Morvan综合征。患者在予以激素冲击治疗和对症治疗后达到临床完全缓解。结论 Morvan综合征可累及青年女性,完善血清CASPR2、LGI1及contactin-2抗体检测可明确诊断;患者需进行肿瘤筛查,免疫治疗有效。
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| 关 键 词： | Morvan综合征 接触蛋白相关样蛋白 富亮氨酸胶质瘤失活蛋白1 肌颤搐 |
A Female Morvan Patient with Contactin-associated Protein 2 and Leucine-rich Glioma Inactivated 1 Antibodies:One Case Report and Literature Review |
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| SUN Jian,ZHU Wen-hua,LUO Su-shan,QIAO Kai,LU Jia-hong,ZHAO Chong-bo.A Female Morvan Patient with Contactin-associated Protein 2 and Leucine-rich Glioma Inactivated 1 Antibodies:One Case Report and Literature Review[J].Chinese Journal of Clinical Neurosciences,2019(3):273-280. |
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| Authors: | SUN Jian ZHU Wen-hua LUO Su-shan QIAO Kai LU Jia-hong ZHAO Chong-bo |
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| Affiliation: | (Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040 , China) |
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| Abstract: | SUN Jian;ZHU Wen-hua;LUO Su-shan;QIAO Kai;LU Jia-hong;ZHAO Chong-bo(Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040 , China) |
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| Keywords: | Morvan syndrome contactin-associated protein 2 leucine-rich glioma inactivated 1 myokymia |
| 本文献已被 CNKI 维普 等数据库收录！ |
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