遗忘型轻度认知障碍与血管紧张素转换酶的基因多态性和血清水平关系的研究

Objective To study the relationship among amnestic mild cognitive impairment(aMCI)and the angiotensin-converting enzyme(ACE)gene polymorphism of intron 16 insertion/deletion(I/D)and serum ACE level.Methods One hundred and eighty subjects(60-85 years)were divided into aMCI group(n=90)and normal control group(n=90)through a series of neuropsychologcal evaluating.The intron 16 I/D polymorphism of ACE gene was analyzed by means of polymerase chain reaction(PCR).The serum ACE levels were measured by using ultraviolet spectrophotometry.Results The scores of neuropsychological tests in aMCI patients were significantly poorer than that in controls(all P＜0.01).The frequencies of DD genotype and D aliele of ACE gene were significantly different between aMCI patients and controls(all P＜0.01).The frequencies of DD genotype and D allele were higher in aMCI patients than controls(23%vs.16%;57%vs.43%).ACE genotype was correlated with delayed recall in Auditory Verbal Memory Test(AVMT),delay recall in Complex Figure Test,Category Fluency Test and Symbol Digit Modalities Test(all P＜0.05),in which DD and DI genotype was lower than Ⅱ genotype(P＜0.05).A significant difference in serum ACE level was observed among the three genotypes in both aMCI and control group(DD＞DI＞II;P＜0.01).AVMT-delay recall had significant correlations with serom ACE level in aMCI group(r=-0.249,P＜0.05).Conclusions The ACE gene I/D polymorphism may be correlated with aMCI,with D allele possibly being a genetic risk factor for the development of aMCI.The higher serum ACE level my possibly play a role in the episodic memory impairment of aMCI.

The angiotensin-converting enzyme gene I/D polymorphism and serum angiotensin-converting enzyme level in patients with amnestic mild cognitive impairment