Incidence of dementia after age 90 in a multiracial cohort |
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| Authors: | Paola Gilsanz Maria M Corrada Claudia H Kawas Elizabeth Rose Mayeda M Maria Glymour Charles P Quesenberry Catherine Lee Rachel A Whitmer |
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| Affiliation: | 1. Kaiser Permanente Division of Research, Oakland, CA, USA;2. Department of Neurology, University of California, Irvine, Irvine, CA, USA;3. Department of Epidemiology, University of California, Irvine, Irvine, CA, USA;4. Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA;5. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA;6. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA;7. Department of Public Health Sciences, University of California, Davis, Davis, CA, USA |
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| Abstract: | IntroductionLittle is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence.MethodsIncident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life.ResultsDementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities.DiscussionPatterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude. |
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| Keywords: | Dementia Disparities Epidemiology Oldest-old Race Ethnicity |
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