脑脊液hs-CRP、IGF-1及IL-6水平与高血压性脑出血神经功能损害程度的相关性

目的 探讨脑脊液超敏C-反应蛋白（hs-CRP）、胰岛素样生长因子-1（IGF-1）、白介素-6（IL-6）水平与高血压性脑出血病人神经功能损伤程度的关系。方法 选择2017年1月~2019年12月收治高血压性脑出血164例和按4:1比例匹配同期行蛛网膜下腔神经阻滞采集脑脊液标本但无神经系统疾病的41例作为对照组。发病6 h、48 h、1周检测脑脊液hs-CRP、IGF-1、IL-6水平，采用美国国立卫生研究院卒中量表（NIHSS）评定神经损害程度。结果 发病6 h，脑出血病人脑脊液hs-CRP、IGF-1、IL-6均明显高于对照组（P<0.05）。发病48 h，脑脊液hs-CRP、IGF-1、IL-6水平及NIHSS评分较发病6 h均明显提高（P<0.05），发病1周较发病6 h均明显降低（P<0.05）。发病6、48 h，脑脊液hs-CRP（r=0.258，P<0.05）、IL-6（r=0.497，P<0.05）水平与NIHSS评分均呈正相关；发病1周，脑脊液hs-CRP、IL-6水平与NIHSS评分均无明显相关性（P>0.05）。发病6 h、48 h、1周，脑脊液IGF-1水平与NIHSS评分均无明显相关性（P>0.05）。结论 脑脊液hs-CRP、IL-6与高血压性脑出血病人神经功能损伤程度呈正相，有望作为评估脑出血进展的有效生物学标志物。

Correlation of cerebrospinal fluid levels of hs-CRP,IGF-1 and IL-6 with neurological impairment of patients with hypertensive cerebral hemorrhage

Objective To analyze the relationship of cerebrospinal fluid (CSF) levels of high-sensitivity-C reactive protein (hs-CRP), insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6) with the neurological impairment of patients with hypertensive cerebral hemorrhage (HCH). Methods The CSF levels of hs-CRP, IGF-1 and IL-6 were detected in 146 patients with HCH (HCH group) 6 h, 48 h, and 1 week after onset and in 41 patients without neurological diseases who underwent subarachnoid nerve block and matched by 4:1 ratio using immune transmission turbidimetric method and enzyme-linked immunosorbent assay, respectively. The neurological impairment was assessed by the National Institutes of Health Stroke Scale (NIHSS) score 6 h, 48 h, and 1 week after onset. Results The CSF levels of hs-CRP, IGF-1 and IL-6 in the HCH group 6 h after onset were significantly higher than those in the control group (P<0.05). The CSF levels of hs-CRP, IGF-1, IL-6 and the NIHSS score in the HCH group, which were signifcantly lower 1 week after onset than 6 h after onset (P<0.05), were significantly higher 48 h after onset than those 6 h after onset (P<0.05). CSF levels of hs-CRP and IL-6 were positively correlated with NIHSS score in the patients with HCH 6 h and 48 h after onset (P<0.05). CSF level of IGF-1 did not correlate with NIHSS score in the patients with HCH 6 h, 48 h and 1 week after onset (P>0.05). Conclusions CSF levels of hs-CRP and IL-6 in the patients with HCH are positively correlated with the neurological impairment, which suggests that they may be effective biological markers for evaluating the progress of cerebral hemorrhage.