高尿酸血症相关脑血管病的研究进展

高尿酸血症与血管内皮功能障碍、动脉粥样硬化及心脑血管事件发生密切相关。高尿酸 血症与卒中发生及预后相关研究的结论存在争议，更多的研究倾向高尿酸血症增加了卒中发生风险， 而在卒中患者预后方面，近期研究表明尿酸水平升高可改善其预后，主要得益于尿酸的抗氧化及神 经保护作用等。同时，高尿酸血症可增加脑小血管病的发生风险，从而引起认知功能下降。

Progress of Hyperuricemia Related Cerebrovascular Diseases

Hyperuricemia is closely related to vascular endothelial dysfunction, atherosclerosis and cardiovascular and cerebrovascular events. The relationship of hyperuricemia with the occurrence and prognosis of stroke is controversial, more studies suggested that hyperuricemia increased the risk of stroke. While recent studies showed that uric acid concentration increase can improve the prognosis, which maybe be related to the antioxidant and neuroprotective effect of uric acid. Meanwhile, hyperuricemia can increase the risk of cerebral small vessel disease, resulting in the decline of cognitive function.