总胆固醇/高密度脂蛋白胆固醇比值与缺血性卒中复发关系研究

目的 探讨急性缺血性卒中90 d内复发与TC/HDL-C比值的关系。 方法 利用急性缺血性卒中患者氧化应激水平临床观察研究（Study on Oxidative Stress in Patients with Acute Ischemic Stroke，SOS-Stroke）数据库的3605例患者作为研究对象，采用多因素Logistic回归 分析急性缺血性卒中患者90 d卒中复发的影响因素。 结果 该研究人群中有231例（6.40%）患者90 d卒中复发，多因素Logistics回归结果显示：年龄（OR 1.02，95%CI 1.00～1.03，P =0.011）、糖尿病史（OR 1.44，95%CI 1.00～2.07，P =0.048）是卒中复发的 危险因素，住院期间服用降脂药物（OR 0.60，95%CI 0.40～0.90，P =0.012）则是卒中复发的保护因素， 急性缺血性卒中患者中TC/HDL-C比值不是卒中复发的预测因素。 结论 TC/HDL-C比值不能预测急性缺血性卒中90 d内复发的风险。

Correlation between Total Cholesterol / High Density Lipoprotein Cholesterol Ratio and Recurrent Stroke in Patients with Acute Ischemic Stroke

Objective To investigate the correlation between TC/HDL-C ratio and recurrent stroke within 90
days after onset in patients with acute ischemic stroke (AIS).
Methods The data of 3605 patients from the Study on Oxidative Stress in Patients with Acute
Ischemic Stroke (SOS-Stroke) were selected. Multivariate logistic regression analysis was used to
analyze the influence factors for recurrent stroke within 90 days after onset in patients with AIS.
Results Recurrent stroke within 90 days occurred in 231 patients (6.40%). Logistic regression
analysis showed that age (OR 1.02, 95%CI 1.00-1.03, P =0.011), history of diabetes (OR 1.44, 95%CI
1.00-2.07, P =0.048) were the risk factors of recurrent stroke, and taking lipid-lowering drugs during
hospitalization (OR 0.60, 95%CI 0.40-0.90, P =0.012) was the protection factor of recurrent stroke.
Conclusions TC/HDL-C ratio can’t predict the risk of recurrent stroke within 90 days after onset
in AIS patients.