Stroke as a cause of death in patients with cancer: a SEER-based study |
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| Affiliation: | 1. Faculty of Medicine, Cairo University, Cairo, Egypt;2. Faculty of Medicine, Ain-Shams University, Cairo, Egypt;3. Gastroenterology, Hepatology and Nutrition diseases, University of Texas, MD Anderson Cancer Center;4. Department of Radiology, Mayo Clinic, Rochester, MN, USA;5. Nuffield Department of Primary Care Health Sciences and Department for Continuing Education (EBHC Program), Oxford University, Oxford, UK;1. Faculty of Medicine, Cairo University, Cairo, Egypt;2. Faculty of Medicine, Ain-Shams University, Cairo, Egypt;3. Gastroenterology, Hepatology and Nutrition diseases, University of Texas, MD Anderson Cancer Center;4. Department of Radiology, Mayo Clinic, Rochester, MN, USA;5. Nuffield Department of Primary Care Health Sciences and Department for Continuing Education (EBHC Program), Oxford University, Oxford, UK;1. College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates;2. School of Pharmacy, Lebanese International University, Beirut, Lebanon;3. School of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), P.O Box: 446, Jounieh lebanon;4. Research Department, Psychiatric Hospital of the Cross, Jal Eddib, Lebanon;6. INSPECT-LB (Institut National de Sant e Publique, d’Épid emiologie Clinique et de Toxicologie-Liban);7. UMR U955 INSERM, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, 94010 Créteil, France;8. École Doctorale Sciences de la Vie et de la Santé, Université Paris-Est Créteil, 94010 Créteil, France;9. Faculty of Pharmacy, Lebanese University, Beirut, Lebanon;10. Faculty of Public health, Lebanese University, Fanar, Lebanon;11. Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus;12. School of Medicine, Lebanese American University, Byblos, Lebanon;13. INSERM U955-E01, IMRB, Henri Mondor Hospital, Créteil, France;14. Department of Neurology, Henri Mondor Hospital, AP-HP, Créteil, France;1. St. Mary''s Hospital, 422 Tsubuku-Honmachi, Kurume, Fukuoka 830-8543, Japan;2. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan;1. Department of Cerebrovascular disease, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, Hainan, China;2. Neurosurgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, Hainan, China;3. Neurosurgery, Hainan Medical University, Haikou 571199, Hainan, China;1. Department of Community Health Nursing, Division of Nursing, Faculty of Medical Sciences, University of Fukui, Japan;2. Department of Neurosurgery, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Japan;3. Department of Computer and Information Science, Faculty of Science and Technology, Seikei University, Japan;4. Department of Neurosurgery, Tsuruga Municipal Hospital, Japan;5. Department of Neurosurgery, Sugita Genpaku Memorial Obama Municipal Hospital, Japan;1. Neurology Department, Hospital Beatriz Ângelo, Loures, Portugal;2. Internal Medicine Department, Hospital Professor Doutor Fernando Fonseca, Portugal;3. Instituto de Saúde Ambiental (ISAMB), Faculdade de Medicina, Universidade de Lisboa, Portugal;4. Stroke Unit, Lisbon Central University Hospital and Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;5. Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;6. Instituto de Medicina Molecular João Lobo Antunes (IMM), Faculdade de Medicina, Universidade de Lisboa, Portugal;7. Department of Neurosciences and Mental Health, Hospital de Santa Maria-CHLN, Faculdade de Medicina, Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal |
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| Abstract: | BackgroundDeath from stroke is linked to cancer due to its pathogenesis and side effects of treatment. Despite this, guidelines regarding identifying cancer patients at the highest risk of mortality from stroke are unclear.AimsTo determine which cancer subtypes are associated with higher risk of death from stroke.MethodsThe National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program was used to obtain data regarding patients with cancer who died of a stroke. We calculated standardized mortality ratios (SMRs) using SEER*Stat software, version 8.4.0.1.ResultsOut of 6,136,803 patients with cancer, 57,523 (0.9%) died from stroke, and this rate was higher than general population (SMR= 1.05, 95%CI 1.04-1.06]). Deaths due to stroke decreased across years, from 24,280 deaths between 2000-2004 to 4,903 deaths between 2015-2019. Of the 57,523 stroke deaths, greatest numbers were observed in cancers of the prostate (n=11,761, 20.4%), breast (n=8,946, 15.5%), colon and rectum (n=7,401, 12.8%), and lung and bronchus (n=4,376, 7.6%). Patients with colon and rectum cancers (SMR= 1.08 95%CI 1.06-1.11]), lung and bronchus cancers (SMR=1.70 95%CI 1.65-1.75]) had a greater rate of death from stroke compared to the general population.ConclusionThe risk of death from stroke in cancer patients is significantly higher than in the general population. Patients with colorectal cancer and lung and bronchus cancer are at higher risk of death by stroke compared to the general population. |
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