同剂量静脉用丙种球蛋白不同方法治疗ABO溶血病的临床观察

为探讨同剂量静脉用丙种球蛋白 (IVIG)不同方法治疗ABO溶血病的疗效。1 7例病人分 2 5gIVIG用 1天组 7例和 1 2 5gIVIG用 2天组 1 0例 ,两组均保持原有的综合治疗。结果显示 ,治疗第二天 ,2 5g组血总胆红素下降 75 2± 1 9 7μmol L ,1 2 5g组下降 2 5 5± 1 1 7μmol L ,P <0 0 0 1。治疗第四天及第七天分别下降 1 2 2 1± 7 4μmol L、81 8± 0 4μmol L及 45 5± 49μmol L、1 1 8 6± 2 1 μmol L(P <0 0 0 1和P <0 0 5)。因此 ,2 5g组 (即IVIG 70 0mg～ 1 0 0 0mg kg)只用 1次疗效优于同剂量分次应用

Clinical observation of ABO hemolysis with the same dosages of intravenous immunoglobulin by different methods

To study the treatment effect of ABO hemolysis with the same dosages of intravenous immunoglobulin by different methods, clinically 17 patients were divided into two groups. One group was 7 cases with 2 5g IVIG once in one day. The other group was 10 cases with 1 25g IVIG once per day within two days. The other therapies were same in the two groups. Result showed the second day after treatment, the serum bilibrubin was decreased 122 1±7 4μmol/L in the group of 2 5g IVIG, and 25 5±11 7μmol/L in the group of 1 25g IVIG(P<0 001). The forth and seventh day, the serum bilirubin was decreased 122 1±7 4μmol/L, 81 8±0 4μmol/L and 45 5±49μmol/L, 118 6±21μmol/L (P<0 001 and P<0 05). The effect of 2 5g IVIG(700mg-1000mg/kg) used at one time was better than that of the same dosages in two divided doses.