CHP1002抗炎镇痛作用评价 |
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引用本文: | 张波,乔磊,冯思良,余晓军,刘克良,宫泽辉.CHP1002抗炎镇痛作用评价[J].军事医学,2012,36(3):173-176. |
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作者姓名: | 张波 乔磊 冯思良 余晓军 刘克良 宫泽辉 |
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作者单位: | 张波 (军事医学科学院毒物药物研究所,北京,100850) ; 乔磊 (军事医学科学院毒物药物研究所,北京,100850) ; 冯思良 (军事医学科学院毒物药物研究所,北京,100850) ; 余晓军 (军事医学科学院毒物药物研究所,北京,100850) ; 刘克良 (军事医学科学院毒物药物研究所,北京,100850) ; 宫泽辉 (军事医学科学院毒物药物研究所,北京,100850) ; |
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基金项目: | 国家科技重大专项资助项目综合性新药研究开发技术平台 |
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摘 要: | 目的研究穿琥宁经PEG修饰的新化合物CHP1002的抗炎镇痛作用。方法分别采用小鼠耳肿胀实验、大鼠足肿胀实验、小鼠醋酸扭体实验观察不同剂量(220,440,880 mg/kg)CHP1002的抗炎镇痛作用,以及给药后不同时间与原型药物的抗炎药效的比较。结果动物腹腔注射CHP1002 440、880 mg/kg剂量组具有抗炎作用(P<0.01),皮下注射CHP1002 440、880 mg/kg剂量组具有镇痛作用(P<0.01)。在给药后不同时间,CHP1002比原型药物的抗炎和镇痛作用延长(P<0.05)。结论经PEG修饰的化合物CHP1002具有抗炎镇痛作用,其作用时间要长于原型药物。
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关 键 词: | 抗炎镇痛 时间因素 聚乙二醇 CHP1002 |
Anti-inflammatory and analgesia effect evaluation of CHP1002 |
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Authors: | ZHANG Bo QIAO Lei FENG Si-liang YU Xiao-jun LIU Ke-liang GONG Ze-hui |
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Affiliation: | *(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China) |
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Abstract: | Objective To evaluate the anti-inflammatory and analgesia effect of a PEG modified compound CHP1002 on animal models.Methods Using the ear swelling test in mice,the paw edema test in rats,and the acetic acid-induced pain test in mice,the anti-inflammatory effect of CHP1002(220,440 and 880 mg/kg) was evaluated and its anti-inflammatory and analgesia effect was compared with the prototype drug at different time after administration.Results In all the three animal models,the anti-inflammatory effect of CHP1002(440 and 880 mg/kg)(P<0.01)was observed,and subcutaneous injection had analgesia effect(P<0.01).In comparison with the prototype drug,the anti-inflammatory and analgesia effect of CHP1002 was prolonged at different time after administration(P<0.05).Conclusion The PEG modified compound CHP1002 has anti-inflammatory and analgesia effect and prolongs the action time. |
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Keywords: | anti-inflammatory analgesia time factors PEG CHP1002 |
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