| 海水和淡水肺内灌注对兔肺损伤作用的实验观察 |
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| 引用本文： | 韩志海,段蕴铀,刘于红,冯华松.海水和淡水肺内灌注对兔肺损伤作用的实验观察[J].中华航海医学与高气压医学杂志,2003,16(1):71-74. |
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| 作者姓名： | 韩志海 段蕴铀 刘于红 冯华松 |
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| 作者单位： | 海军总医院呼吸科,北京,100048;海军总医院重症监护室,北京,100048; |
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| 摘 要： | Objective To investigate differences in lung injury induced by seawater and freshwater perfusion in rabbits. Methods 21 New Zealand rabbits were randomly divided into the normal group (the control group), the freshwater group and the seawater group. Same amounts of seawater and freshwater were perfused in the lungs of rabbits through tracheal incubation. Changes in the indices concerning symptomatology, blood-gas, hemodynamics, tumor necrosis factor (TNF-α), interleukin 6 (IL-6), histology and lung injury were monitored 3 hours later. Then, the obtained data were analyzed statistically to see the differences in lung lesions of different animal groups. Results Blood-gas analysis, inflammatory factor measurement, lung injury score indicated that seawater and freshwater perfusion could all induce lung injury to a certain extent, and the injury induced by seawater perfusion was obviously severer(P<0.05). Conclusions Lung injury induced by seawater perfusion is severer than that by freshwater perfusion.
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| 关 键 词： | 海水灌注 淡水灌注 肺损伤 |
Effects of seawater and freshwater perfusion on lung injury in rabbits |
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| HAN Zhi-hai,DUAN Yun-you,LIU Yu-hong,FENG Hua-song.Effects of seawater and freshwater perfusion on lung injury in rabbits[J].Chinese Journal of Nautical Medicine and Hyperbaric Medicine,2003,16(1):71-74. |
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| Authors: | HAN Zhi-hai DUAN Yun-you LIU Yu-hong FENG Hua-song |
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| Abstract: | |
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| Keywords: | Seawater perfusionFreshwater perfusionLung injury |
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