Localized 1H-MR Spectroscopy in Moyamoya Disease before and after Revascularization Surgery |
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| Authors: | Soo Mee Lim Hye-Young Choi Jung Soo Suh Jung Hee Lee Keun Ho Lim Dae Chul Suh Ho Kyu Lee Tae-Hwan Lim and Young Shin Ra |
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| Affiliation: | 1Department of Diagnostic Radiology, College of Medicine, Ewha Womans University Hospital, Seoul, Korea.;2NMR Laboratory, Asan Institute for Life Sciences, Korea.;3Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.;4Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. |
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| Abstract: | ObjectiveTo evaluate, using localized proton magnetic resonance spectroscopy (1H-MRS), the cerebral metabolic change apparent after revascularization surgery in patients with moyamoya disease.Materials and MethodsSixteen children with moyamoya disease and eight age-matched normal controls underwent MR imaging, MR angiography, conventional angiography, and 99mTc-ECD SPECT. Frontal white matter and the basal ganglia of both hemispheres were subjected to localized 1H-MRS, and after revascularization surgery, four patients underwent follow-up 1H-MRS.ResultsDecreased NAA/Cr ratios (1.35±0.14 in patients vs. 1.55±0.24 in controls) and Cho/Cr ratios (0.96±0.13 in patients vs. 1.10±0.11 in controls) were observed in frontal white matter. After revascularization surgery, NAA/Cr and Cho/Cr ratios in this region increased. In the basal ganglia, there is no abnormal metabolic ratios.ConclusionLocalized 1H-MRS revealed abnormal metabolic change in both hemispheres of children with moyamoya disease. Because of its non-invasive nature, 1H-MRS is potentially useful for the preoperative evaluation of metabolic abnormalities and their postoperative monitoring. |
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| Keywords: | Magnetic resonance (MR) spectroscopy Brain infarction Moyamoya disease |
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