Understanding the postmortem changes in concentrations of methanol in ocular matrices in rabbits |
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| Affiliation: | 1. Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India;2. Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, New Delhi, India;3. Department of Ocular Pharmacology and Pharmacy, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India;1. Department of Forensic Analytical Toxicology, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China;2. Department of Legal Medicine, College of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, China;1. Forensic DNA Typing Laboratory, Centre of Excellence in Molecular Biology, University of the Punjab Lahore 53700, Pakistan;2. Faculty of Life Sciences and Informatics, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta (BAUITEMS), Pakistan;1. Università degli Studi di Udine, Dipartimento di Area Medica, Medicina Legale, Italy;2. Azienda Sanitaria Friuli Occidentale (ASFO), Dipartimento di Prevenzione, SOSD di Medicina Legale, Italy;1. Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur 342005, India;2. School of Forensic Sciences, National Forensic Sciences University, Tripura 799001, India;3. Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur 342005, India;4. Department of Anatomy, All India Institute of Medical Sciences, Jodhpur 342005, India;5. Department of Anthropology, (UGC Centre of Advanced Study), Panjab University, Chandigarh 160014, India |
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| Abstract: | Death due to abuse and accidental ingestion of methanol is widely known around the globe. The paper presents the postmortem changes in concentrations of methanol in the vitreous humor, aqueous humor, and ocular tissues in a rabbit model in methanol intoxication. Rabbits were intoxicated with methanol at a dose of 6.3 ml/kg through oral gavage. After 3.5 h of methanol administration, the rabbits were sacrificed. Vitreous humor, aqueous humor, and ocular tissues were collected both, perimortem (immediately) and postmortem (17 h post-death). Whole blood and plasma samples were also collected to explore the correlation between levels of methanol in whole blood/plasma and ocular fluids/ocular tissues if any. All the samples were analyzed by Headspace Gas Chromatography. The analysis revealed a decrease in methanol levels at postmortem for all the matrices, except for retina-choroid than its perimortem value. For retina-choroid, no significant change in methanol levels at postmortem was found. |
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| Keywords: | Methanol Vitreous humor Ocular tissues Postmortem Whole blood Rabbits |
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