氢质子磁共振波谱在小儿颞叶癫痫研究中的应用

目的 结合MRI和脑电图（EEG）所见，评价氢质子磁共振波谱（^1H MRS)在小儿颞叶癫痫诊断中的价值。方法 对10例颞叶癫痫患儿和8例健康自愿儿用2．0T场强MR扫描系统进行MRI及^1H MRS采集。测定N－乙酰天门冬氨酸（NAA）、胆碱（Cho)、肌酸（Cr)、乳酸（Lac)、肌醇（MI）、谷氨酸及谷氨酰胺（Glu/Gln)等代谢产物。结果 以NAA／（Cr Cho)值为标准，海马硬化侧组及脑电图异常侧组与对照组间比较，差异有显著性意义（平均差异分别为0．7663、0．6190，P＜0．05）。结论 ^1H MRS在小儿颞叶癫痫灶诊断的敏感性高于MRI，且有助于脑电图定位诊断。

Proton MR spectroscopy in the diagnosis of children with temporal lobe epilepsy

Objective To evaluate the value of proton magnetic resonance spectroscopy ( 1H MRS) with combination of magnetic resonance imaging (MRI) and electroencephalogram (EEG) in the diagnosis of the changes of brain biochemistry in children with temporal lobe epilepsy (TLE). Methods 1?H MRS was performed in 10 children with TLE and 8 healthy volunteers on a 2.0 T MRI/MRS system. The metabolites included N acetylaspartate (NAA), choline containing compounds (Cho), creatine and phosphocreatine (Cr), myo inositol (MI), glutamate and glutamine (Glu/Gln), and lactate (Lac). Results The value of NAA/(Cr+Cho) of the abnormal side on EEG and the abnormal side of hippocampal sclerosis decreased evidently compared with that of the control group ( P <0.05). Conclusion 1?H MRS is more sensitive than MRI in the diagnosis of children with TLE. Moreover, MRS is helpful for the localization of EEG.