中国汉族正常成人尾状核的高分辨率MRI测量

目的 测量中国汉族正常成人尾状核体积,为建立中国成人数字标准脑提供基础数据.方法 采用全国多中心临床研究形式,选取18～70岁健康志愿者1000名,按照年龄18～30、31～40、41～50、51～60、61～70岁进行分组,每组男、女各100名.所有受试者均行三维磁化强度预备梯度回波序列T1WI,应用三维体积分析软件手工勾绘ROI,测量尾状核的体积,探讨尾状核体积的性别、侧别差异及与年龄的相关关系.组间比较采用独立样本t检验,年龄与体积进行Pearson相关分析,左、右两侧对照使用配对t检验.结果 正常中国成人两侧尾状核体积之和为(10.973 ±1.647)cm3.男性左、右侧尾状核体积分别为(5.656±0.860)、(5.671±0.855)cm3,差异无统计学意义(t=1.230,P>0.05).女性左、右侧尾状核体积分别为(5.287±0.774)、(5.331±0.766)cm3,右侧大于左侧(t=3.999,P<0.01).相关性分析示男、女性的左、右侧尾状核体积均与年龄呈明显负相关(r值分别为-0.561、-0.568、-0.548、-0.552,P值均<0.05).结论 高分辨率MRI和三维体积分析软件可以准确测量尾状核的体积,为中国成人数字标准脑提供基础性数据.

Measuring the volume of caudate nucleus in healthy Chinese adults of the Han nationality on the high-resolution MRI

Objective To explore the normal range of the caudate nucleus' volume in Chinese adults of the Han nationality and provide morphological data for the construction of database for Chinese Standard Brain.Methods This was a clinical multi-center study.One thousand Chinese healthy volunteers (age range=18 to 70)recruited from 16 hospitals were divided into 5 groups,i.e.,Group A(age range=18 to 30),B(age range=31 to 40),C(age range=41 to 50),D(age range=51 to 60),and E(age range=61 to 70).Each group contained 100 males and 100 females.All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence.The volume of eaudate was measured manually using 3D volume analysis software.The difierence of volumes of the eaudate between male and female were analyzed by independent sample t-test,and among age groups by ANOVA.Pearson's correlation coefficient was used to characterize the relationship between volunles and age.The differences of measurements between left and right caudate nucleus were analyzed by paired t test.Results (1)rnle mean volume of bilateral caudate nucleus in healthy Chinese adults wag(10.973±1.647)cm3.The mean volume of the the male's left and right caudate nucleus were(5.656±0.860)and (5.671±0.855)cm3 respectively,no significant differences were found between the volume of left and right eaudate nucleus(t=1.230.P>0.05).The mean volume of the the female's left and right eaudate nucleus were(5.287±0.774)and(5.331±0.766)cm3 respectively,and the right's wag larger than the left's with significant differences(t=3.999,P<0.01);(2)Pearson correlation analysis showed a significant negative correlation between the nucleus volume and age(male and female's,left and fight)(r=-0.561,-0.568,-0.548,-0.552,P<0.05).Conclusion With high-resolution MRI and 3D volumetric analytic software(Midob),the volume of the caudate nucleus can be accurately measured,so as to provide the basic data for establishing Chinese adults' standard digital brain.and provide nomad control standards for caudate nucleus volume-related diseases.