尾吊大鼠血液细胞电阻抗谱的Cole-Cole模型分析

目的利用Cole-Cole数学模型研究尾吊大鼠血液细胞电阻抗频谱的变化。方法通过非线性数值计算,对血液细胞的Bode图,Nyquist图和Nichols图进行Cole-Cole方程的曲线拟合,比较对照组(Con)与尾吊组(SUS)Cole-Cole模型参数。结果尾吊60 d大鼠血液细胞电阻抗频谱Cole-Cole模型参数变化显示:阻抗高频极限值(R∞)和阻抗增量(ΔR1,ΔR2)减小;特征频率(fC1,fC2)和β驰豫散射角(α1,α2)增加。结论可以通过Cole-Cole数学方程参数表达尾吊大鼠血液细胞电阻抗频谱特性变化。

Analysis of Electrical Impedance Spectroscopy of Blood Cells in Tail-Suspension Rats with Cole-Cole Models

Objective To study the changes of electrical impedance spectrum(EIS) of blood in tail-suspended rats by using the Cole-Cole mathematical model.Methods The difference in the Cole-Cole model parameters of blood cells were compared between the control group(Con) and the tail suspension group(SUS) with the curve fitting in the Bode diagram,the Nyquist diagram and Nichols diagram by non-linear numerical calculation of the Cole-Cole equation.Results The changes of Cole-Cole model parameters in rats’ blood after 60 d tail-suspension were as follows: High-frequency limit of impedance(R∞) and the impedance increment(ΔR1,ΔR2) decreased;the characteristic frequency(fC1,fC2) and the β dispersion angle(α1,α2) increased.Conclusion The changes of electrical impedance spectral characteristics of blood cells in tail suspended rats can be expressed by the parameters of the Cole-Cole mathematical equation.