首页 | 官方网站   微博 | 高级检索  
     

颞叶癫痫定位诊断的磁共振波谱研究
引用本文:王志群,李坤成,王亮,秦文.颞叶癫痫定位诊断的磁共振波谱研究[J].放射学实践,2007,22(4):371-375.
作者姓名:王志群  李坤成  王亮  秦文
作者单位:100053,北京,首都医科大学宣武医院放射科
摘    要:目的:探讨氢质子磁共振波谱(1H-MRS)对颞叶癫痫(TLE)定位诊断的应用价值.方法:选择15例经手术和病理证实的TLE患者和15例性别、年龄与之相匹配的健康志愿者为研究对象,分别作双侧颞叶内侧的1H-MRS,并对双侧海马区域进行精确定位,通过计算峰下面积,对代谢产物氮-乙酰天门冬氨酸(NAA)、肌酸(Cr)及胆碱复合物(Cho)的浓度进行相对定量分析.结果:采用Kappa检验,两位医师对海马硬化诊断的一致性K值=0.80(P<0.05),表明一致性很好,MRI可对10例患者作出术前定位.MRS示TLE患侧组NAA/(Cho Cr)为0.37±0.07,对照组和TLE对侧组则分别为0.65±0.07和0.62±0.18,差异有显著性意义(F值为23.170,P<0.05);MRS定位准确12例,另3例为阴性,结合MRI可对13例准确定位.结论:1H-MRS能敏感地探测到神经元的异常改变,为颞叶癫痫的术前定位提供了一种新的检查方法,其与MRI相结合可提高术前定位的准确率.

关 键 词:磁共振波谱学  癫痫  颞叶  定位诊断  磁共振成像
文章编号:1000-0313(2007)04-0371-05
修稿时间:07 17 2006 12:00AM

Evaluation of Proton Magnetic Resonance Spectroscopy for Localization of Temporal Lobe Epilepsy
WANG Zhi- qun, LI Kun- cheng,WANG Liang,et al..Evaluation of Proton Magnetic Resonance Spectroscopy for Localization of Temporal Lobe Epilepsy[J].Radiologic Practice,2007,22(4):371-375.
Authors:WANG Zhi- qun  LI Kun- cheng  WANG Liang  
Affiliation:Department of Radiology, Xuanwu Hospital, Capital University of Medical Science, Beijing 100053 ,P. R. China
Abstract:Objective:To evaluate the value of proton magnetic resonance spectroscopy (1H-MRS)in the localization diagnosis (LD) of temporal lobe epilepsy (TLE).Methods:15 selected patients with TLE verified by operation and pathology and 15 healthy volunteers were studied,spectra were obtained in the region of both temporal lobes separately and exact localization was performed in the region of both hippocampuses.The values of N-acetylaspartate (NAA),Creatine (Cr) and Choline (Cho) were calculated by integration of their peaks,and the relative ratios of them were analyzed.The diagnostic value of 1H-MRS for the LD of TLE was analyzed.Results:It was very good that there exists a consistency of hippocampus sclerosis diagnosis between two radiologists.The value of K was 0.80 according to Kappa test.MRI abnormalities were found in 10 cases.The ipsilateral group of TLE patients had lower ratios of NAA/(Cho+Cr),and the differences compared with those of the normal group and contra-lateral subgroup were statistically significant (F=23.170,P<0.05).1H-MRS was positive in 12 cases and negative in the other 3 cases.Combination of 1H-MRS with MRI can make the accuracy cases of LD raising to 13.Conclusion:1H-MRS is sensitive to the neuron abnormality.It provides a new method for the LD of TLE.Combination of MRS with MRI can improve the accuracy ratio of the LD.
Keywords:Magnetic resonance spectroscopy  Epilepsy  temporal lobe  Localization diagnosis  Magnetic resonance imaging
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《放射学实践》浏览原始摘要信息
点击此处可从《放射学实践》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号