介入化疗加后装放射治疗复发性鼻咽癌的近期疗效观察

目的 探讨介入化疗辅加后装放射治疗复发性鼻咽癌的临床疗效。方法 32例复发性鼻咽癌分为：16例介入化疗辅加后装放射治疗组，介入化疗术后第3天作首次后装放射治疗，4d后行第2次后装放射治疗。16例单纯行后装放射治疗。剂量及2次间隔时间2组相同，每次5GY。复查时间统一在后装放疗后2周。结果 介入化疗辅加后装放射治疗组，临床症状改善明显，局部肿大淋巴结明显缩小，鼻咽部肿瘤表面分泌滞留极少或消失，肿瘤明显缩小，并呈干枯或萎缩样变；单纯后装放射治疗组，临床症状改善不明显，除鼻咽部肿瘤表面分泌物较治疗前有所减少外，局部肿大淋巴，鼻咽部肿瘤红肿充血与放疗前无明显改变。介入组未见有肝肾功能损害及明显术后消化道反应。结论 介入化疗辅加后装内照射治疗复发性鼻咽癌具有双重直接局部杀伤杀死肿瘤细胞作用，是治疗复发性鼻咽癌的一种新的治疗途径。

The study of short-term curative effect for recurring NPC with the treatment of intracavitary brachytherapy after interventional chemotherapy

Objective To evaluate the clinical curative effect and methods for recurring NPC with treatment of intracavitary radiotherapy after interventional chemotherapy. Methods 32 cases of recurring NPC were divided into two groups, each of which consisted of 16 cases. Group one was treated with intracavitary chemotherapy plus intracavitary radiotherapy. On the third day after interventional chemotherapy, the first intracavitary radiotherapy was performed (5 Gy) and the second treatment was done next day. Group two was only performed with intracavitary radiotherapy. The dose and interval were the same. The time of re examination was two weeks later. Results In the first group, clinical symptoms were improved, local swelling lymph nodes were shrunk, secretion on the nasopharyngeal surface was hardly left or disappeared. Tumours were shrunk and atrophy. On the intracavitary radiotherapy group, clinical symptoms changed a little, except the secretion on the mass surface was reduced. The white blood counts of the two groups showed no difference and there were no functional changes of liver, kidney and digestive system in the interventional group. Conclusions It is a new and effective therapy to treat recurring NPC with interventional chemotherapy plus intracavitary radiotherapy.