Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity |
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Authors: | Pereverzeva E Treschalin I Bodyagin D Maksimenko O Langer K Dreis S Asmussen B Kreuter J Gelperina S |
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Affiliation: | Gauze Institute of Novel Antibiotics, Academy of Medical Sciences, Moscow, Russia. |
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Abstract: | A toxicological study of doxorubicin bound to poly(butyl cyanoacrylate) or human serum albumin nanoparticles coated with polysorbate 80 was performed in healthy rats. The doxorubicin formulations were injected at a therapeutic dose regimen (3 x 1.5 mg/kg with a 72 h interval), and the animals were followed up for 15 or 30 days. The overall result of this study suggests that the surfactant-coated nanoparticle formulations of doxorubicin have favorable toxicological profiles. Specifically, these formulations display a considerably reduced cardio- and testicular toxicity, as compared to a free drug. |
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