维生素E抑制冠心病患者低密度脂蛋白氧化修饰作用的临床研究

目的探讨维生素E(VitE)对冠心病低密度脂蛋白氧化修饰作用。方法健康对照组32例,将45例冠心病患者分两个剂量组 ,VitE0.1g/d及0.3g/d。采用给药前后自身对照的方法测定血清氧化低密度脂蛋白(oxLDL)、血清脂质过氧化物(LPO)、全血谷胱甘肽过氧化酶(GSH_Px)、全血超氧化物歧化酶(SOD)。结果冠心病组oxLDL、LPO显著升高(P<0.01,P<0.05),GSH_Px显著降低(P<0.01)。VitE0.3g/d治疗后 ,oxLDL和LPO显著降低(P<0.01) ,GSH_Px升高(P<0.01)。结论VitE是一种良好的抗氧化剂 ,其抑制低密度脂蛋白的氧化修饰作用是防治冠心病的重要机制之一

Clinical ivestigation of vitamin E on the oxidation of low density lipoprotein in coronary heart disease

Aim The effect of Vitamin E on the oxidation of low denity lipoprotein in coronary heart disease (CHD) was abserued.Methods In 32 healthy control persons and 45 CHD patients, who were divided into two groups and given Vitmin E 0.1 g qd or 0.1 g tid, po for 4 weeks, the contents of oxidized low density lipoprotein oxLDL ,lipid peroxides (LPO)in serum and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood were examined before and after treatment. Results The oxLDL and LPO were significantly higher in CHD patients than in the controls.After treatment with Vitmin E 0.1 g tid oxLDL and LPO decreased significantly (P<0.01) and GSH-Px activity increased markedly (P<0.01).Conclusion Vitamin E was a free radical scavenger and its inhibiting oxidative modification of LDL may be one of its machenisms for prevention and treatment of CHD.