| 柚皮苷对人卵巢癌SKOV3细胞P38MAPK及ERK1/2蛋白表达的影响 |
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| 引用本文： | 胡昕,宋淑慧,熊玉卿,蔡丽萍.柚皮苷对人卵巢癌SKOV3细胞P38MAPK及ERK1/2蛋白表达的影响[J].中国临床药理学与治疗学,2013,18(5):519-523. |
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| 作者姓名： | 胡昕 宋淑慧 熊玉卿 蔡丽萍 |
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| 作者单位： | 1. 南昌大学第一附属医院妇产科,南昌330006,江西
2. 江西医学院临床药理研究所,南昌330006,江西 |
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| 摘 要： | 目的:探讨中药柚皮苷对人卵巢癌SK-OV3细胞P38MAPK及ERK1/2蛋白表达水平的影响.方法:体外培养人卵巢癌SKOV3细胞,分为空白对照组、柚皮苷10、20、40 μmol/L组、塞来昔布80 μmol/L组.Western Blot测定培养48 h后各组细胞中P38MAPK及ERK1/2蛋白表达水平.结果:Western Blot结果显示,与空白对照组相比,低浓度柚皮苷组(10、20 μmol/L)对SKOV3细胞P38MAPK及ERK1/2蛋白的表达无明显影响,而40 μmol/L柚皮苷及塞来昔布组可明显下调P38MAPK及ERK1/2蛋白表达,具有统计学差异(P＜0.05).结论:柚皮苷能抑制人卵巢癌SKOV3细胞P38MAPK及ERK1/2蛋白的作用,从而可能阻断卵巢癌的发生、发展.
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| 关 键 词： | 柚皮苷 P38MAPK ERK1/2 卵巢癌 SKOV3细胞 |
Effects of Naringin on expression of p38MAPK and ERK1/2 signaling proteins of Human ovarian cancer cell line SKOV3 |
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| HU Xin,SONG Shu-hui,XIONG Yu-qing,CAI Li-ping.Effects of Naringin on expression of p38MAPK and ERK1/2 signaling proteins of Human ovarian cancer cell line SKOV3[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2013,18(5):519-523. |
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| Authors: | HU Xin SONG Shu-hui XIONG Yu-qing CAI Li-ping |
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| Affiliation: | 1 Department of Gynecology and Obstetrics,the First Affiliated Hospital of Nanchang University;2 Institute of Clinical Pharmacology,Jiangxi Medical College,Nanchang University,Nanchang 330006,Jiangxi,China) |
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| Abstract: | AIM： To investigate effects of Naringin on expression of P38MAPK and ERK1/2 signaling proteins of Human ovarian cancer cell line SKOV3.METHODS： SKOV3 cell were cultured in vitro and divided into five groups randomly,namely control group,naringin group（10 μmol/L）,naringin group（20 μmol/L）,naringin group（40 μmol/L） and celecoxib group（80 μmol/L）.The expression of P38MAPK and ERK1/2 signaling proteins were determined by Western Blot after forty-eight hours.RESULTS：Compared with control group,only naringin group（40 μmol/L） and celecoxib group can significantly cut P38MAPK and ERK1/2 signaling proteins,the difference was statistically significant（P〈0.05）.CONCLUSION： Naringin can inhibit P38MAPK and ERK1/2 signaling proteins of SKOV3 cell,thus may block the occur and development of ovarian cancer. |
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| Keywords: | Naringin P38MAPK ERK1/2 Ovarian cancer Cell SKOV3 |
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