头孢噻肟在恶性血液病合并感染患者体内杀菌效价及临床疗效比较

目的 对比观察头孢噻肟（ＣＴＸ）与其他两种抗菌药物治疗方案对３０例血液病合并感染患者杀 菌活性（ＳＢＡ）及临床疗效。方法ＳＢＡ采用微量稀释法测定，临床疗效根据临床治疗登记表按三 级标准判定。结果与结论 头孢噻肟的临床反应最佳，杀菌作用时间维持较长，但对绿脓假单胞 菌和阴沟肠杆菌杀菌作用较差；呱拉西林（ＰＩＰ）与阿米卡星（ＡＮ）方案的抗菌谱广，但ＰＩＰ杀菌 作用时间较短，可考虑缩短给药间期，而ＡＮ可按一日一次给全日量的方案，以提高疗效减少不 良反应；头孢哌酮（ＣＰＺ）可主要用于绿脓假单胞菌感染，也可用于其它细菌的混合感染，但给药 间隔时间以一日三次为宜。

Study on the serum bactericidal activity and clinical effects of cefotaxime in patients with hematopathy and infection complication

Aim The serum bactericidal action (SBA) of cefotaxime and its clinical effect were observed and compared with two schedules of antimicrobial chemotherapy in patients with hematopathy complicated by infection. Methods Thirty patients in 3 groups were treated with cefotaxime (CTX), piperacillin plus amikacin (PIP AN) and cefoperazone (CPZ) respectively. The SPA was determined by microdiluted method and the clinical effect was judged according to the records of symptoms and clinical effect was judged according to the records of symptoms and clinical findings recorded before and after treatment. Results In comparison with CPZ and PIP AN, CIX had better SBA and longer antimicrobial time. As to against defferent strains of infection - causing bacteria the SBA of CTX to Ps aeruginose and E cloacea was weak, while PIP AN had a broader antimicrobial spectrum, but the antibacterial time of PIP was short. Among the three antimicrobials there was no statistical defference in clinical effect. Conclu- sion To enhance the efficacy and reduce adverse reaction the dosing time should be regu- lated. It is recommended that piperacillin and cefoperazone be given three times daily, cefo- taxime twice a day and amikacin once a day.